Ishimori1: Plasma HDL cholesterol, obesity, and atherosclerosis susceptibility in F2 progeny from a C57BL/6J x 129S1/SvImJ intercross (2004)

Ishmori N, Churchill GA   With: Li R, Kelmenson PM, Korstanje R, Walsh KA, Forsman-Semb K, Paigen B

     
Ishimori1 downloads
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Participants N Ishmori
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Li R, Kelmenson PM, Korstanje R, Walsh KA, Forsman-Semb K, Paigen B
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsFunding provided by NIH Grants CA34196, HL66611 and AR43618; AstraZeneca; Japan Heart Foundation/BayerYakuhin Research Grant Abroad; Japan Heart Foundation/Pfizer Grant for Research on Hypertension, Hyperlipidemia, and Vascular Metabolism.
Project type QTL Archive data set
MPD identifiersIshimori1     MPD:140
Data changelog No updates/corrections.       Initial release date: 01/2008.
An intercross between C57BL/6J and 129S1/SvImJ inbred mouse strains was generated to identify QTLs involved in plasma HDL cholesterol concentrations, obesity, and susceptibility to atherosclerosis. Body and liver weight, body composition, bone mineral density, blood lipids, parathyroid hormone levels, and aortic lesion size were measured in mice administered a high-fat (15%) diet from 6-20 wks of age (14 wks on high fat diet). Plasma was obtained from fasted mice (4 hr). For detailed protocols see publications (below).


QTL data set parameters:
Progenitor strains 129S1/SvImJ     C57BL/6J    
Cross direction notation(B6x129) F1 x (B6x129) F1
Cross typeF2 intercross
Population size 294 ♀     0 ♂
Age20wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Ishimori1 14001 body weight high fat diet  14wks body weight   [g]  bw QTL population f 20wks N=294
Ishimori1 14002 organ weights high fat diet  14wks liver weight   [g]  liver_wt QTL population f 20wks N=294
Ishimori1 14003 lipid profile high fat diet  14wks HDL cholesterol (plasma)   [mg/dL]  HDLC QTL population f 20wks N=294
Ishimori1 14004 lipid profile high fat diet  14wks HDL cholesterol (plasma), log transformed   [log(mg/dL)]  HDLC_log QTL population f 20wks N=294
Ishimori1 14005 lipid profile high fat diet  14wks non-HDL cholesterol (plasma)   [mg/dL]  nonHDLC QTL population f 20wks N=294
Ishimori1 14006 lipid profile high fat diet  14wks non-HDL cholesterol (plasma), log transformed   [log(mg/dL)]  nonHDL_log QTL population f 20wks N=294
Ishimori1 14007 lipid profile high fat diet  14wks total cholesterol (plasma)   [mg/dL]  chol QTL population f 20wks N=294
Ishimori1 14008 lipid profile high fat diet  14wks triglycerides (plasma)   [mg/dL]  TG QTL population f 20wks N=294
Ishimori1 14009 histopathology high fat diet  14wks fatty streak aortic lesions (0=absent, 1=present)   [score]  aortic_lesion_presence QTL population f 20wks N=294
Ishimori1 14010 histopathology high fat diet  14wks fatty streak aortic lesion size   [µm2]  aortic_lesion QTL population f 20wks N=294
Ishimori1 14011 histopathology high fat diet  14wks fatty streak aortic lesion size, log transformed   [log(µm2)]  aortic_lesion_log QTL population f 20wks N=294
Ishimori1 14012 DXA high fat diet  14wks total body area bone mineral density   [mg/mm2]  BMD_total QTL population f 20wks N=294
Ishimori1 14013 DXA high fat diet  14wks vertebral areal bone mineral density   [mg/mm2]  BMD_vertebral QTL population f 20wks N=294
Ishimori1 14014 DXA high fat diet  14wks percent of body weight that is fat   [%]  pct_fat QTL population f 20wks N=294
Ishimori1 14015 body weight high fat diet  14wks body mass index (BMI)   [g/cm2]  BMI QTL population f 20wks N=294
Ishimori1 14016 body weight high fat diet  14wks body mass index (BMI), log transformed   [log(g/cm2)]  BMI_log QTL population f 20wks N=294
Ishimori1 14017 hormone quantification high fat diet  14wks parathyroid hormone   [pg/mL]  PTH QTL population f 20wks N=294
Ishimori1 14018 hormone quantification high fat diet  14wks parathyroid hormone, log transformed   [log(pg/mL)]  PTH_log QTL population f 20wks N=294
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Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Aorls1   Ath17   Ath18   Ath19   Ath20   Ath21   Bmd20   Bmd21   Bmd22   Bmd9   Hdlq14   Hdlq15   Hdlq16   Hdlq17   Hdlq18   Hdlq19   Mobq2   Nhdlq1   Nhdlq4   Nhdlq5   Nhdlq6   Nhdlq7   Obq16   Obq17   Obq18   Obq19   Tgq1   Tgq2   Tgq3  


Project / data set:   Ishimori1     a.k.a. Ishimori_2004
Excel file:   Data_Description_B6x129_Ishimori2004.xlsx
CSV file:   Ishimori2004_B6x129_B37_Data.csv
Readme / text file:   readme_Ishimori2004.txt
QC plots, figures, etc.:   QCReport_Ishimori2004.pdf


References   (chronological)

1.   Ishimori N, Li R, Kelmenson PM, Korstanje R, Walsh KA, Churchill GA, Forsman-Semb K, Paigen B. Quantitative Trait Loci Analysis for Plasma HDL-Cholesterol Concentrations and Atherosclerosis Susceptibility Between Inbred Mouse Strains C57BL/6J and 129S1/SvImJ. Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):161-6. Epub 2003 Oct 30.   PubMed 14592847  

2.   Ishimori N, Li R, Kelmenson PM, Korstanje R, Walsh KA, Churchill GA, Forsman-Semb K, Paigen B. Quantitative trait loci that determine plasma lipids and obesity in C57BL/6J and 129S1/SvImJ inbred mice. J Lipid Res. 2004 Sep;45(9):1624-32. Epub 2004 Jun 21.   PubMed 15210844  

3.   Ishimori N, Li R, Walsh KA, Korstanje R, Rollins JA, Petkov P, Pletcher MT, Wiltshire T, Donahue LR, Rosen CJ, Beamer WG, Churchill GA, Paigen B. Quantitative trait loci that determine BMD in C57BL/6J and 129S1/SvImJ inbred mice. J Bone Miner Res. 2006 Jan;21(1):105-12. Epub 2005 Sep 9.   PubMed 16355279  

4.   Ackert-Bicknell CL, Karasik D, Li Q, Smith RV, Hsu YH, Churchill GA, Paigen BJ, Tsaih SW. Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map. J Bone Miner Res. 2010 Aug;25(8):1808-20.   PubMed 20200990