Ontology terms mapped to HMDPpheno11 measures:

  MA:0000062   aorta
  MP:0005340   altered susceptibility to atherosclerosis MGI
  MP:0020098   abnormal susceptibility to diet-induced aortic fatty streak lesions MGI
  VT:0000272   aorta morphology trait

Investigators	Brian J Bennett       University of North Carolina,  Chapel Hill, NC Aldons J Lusis       University of California, Los Angeles,  Los Angeles, CA
Participants	Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS
Contact	Aldons J Lusis     jlusis@mednet.ucla.edu     Lab web site
Affiliated Center	Hybrid Mouse Diversity Panel Group (HMDP)
Acknowledgements	Mice carrying the human ApoE3 Leiden variant were kindly provided by Dr. L. Havekes, Leiden University Medical Center, Leiden, Netherlands
Funding Provided By	Funding provided by NIH HL103866, HL113452, HL30568, HL28481, HL102223, HL121172; Transatlantic Networks of Excellence Award (12CVD03) from Foundation Leducq
Project type	Phenotype strain survey data set
MPD identifiers	HMDPpheno11     MPD:1013
Data changelog	No updates/corrections.       Initial release date: 01/2020.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Male C57BL/6J mice carrying the dominant human transgenes for ApoE*3 Leiden variant and CETP were crossed with females of approximately 100 inbred strains from the Hybrid Mouse Diversity Panel (HDMP). At the age of 8 weeks, F1 progeny carrying both transgenes were placed on a high-fat diet supplemented with 1.0% cholesterol. Test mice were euthanized at approximately 24 weeks of age, and the lesion area in the proximal aorta was assessed.

Experimental groups in this study:
• high-fat high-cholesterol diet    

Procedures conducted:

• histopathology

Aortic lesion size after 16 wks on high-fat diet.