Guay-Woodford1: Kidney parameters predicting renal cystic disease severity in F2 progeny of BALB/c-Bicc1jcpk-bpk and CAST/EiJ (2000)

Guay-Woodford LM, Wright CJ, Walz G, Churchill GA. Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model. J Am Soc Nephrol. 2000 Jul;11(7):1253-60.   PubMed 10864581  


     
Guay-Woodford1 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Participants L M Guay-Woodford
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Guay-Woodford LM, Wright CJ, Walz G, Churchill GA
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsFunding provided by NIH DK51034
Project type QTL Archive data set
MPD identifiersGuay-Woodford1     MPD:107
Data changelog No updates/corrections.       Initial release date: 01/2008.
An intercross between BALB/c-Bicc1jcpk-bpk and CAST/EiJ was generated to identify QTLs that modulate renal cystic disease severity. Kidney parameters were measured in F2 (bpk/bpk) mice at 12-16 days of age. For detailed protocols see Guay-Woodford et al 2000.


QTL data set parameters:
Progenitor strains BALB/c-Bicc1jcpk-bpk     CAST/EiJ    
Cross direction notation(BALBxCAST) F1 x (BALBxCAST) F1
Cross typeF2 intercross
Population size 144 ♀     0 ♂
NotesSex not specified; arbitrarily set to female. Data are from F2-/- pups.
Age2wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Guay-Woodford1 10701 body size and weight (none) body length from crown to rump (CR)   [cm]  body_length QTL population f 2wks N=144
Guay-Woodford1 10702 organ dimensions (none) length of kidney   [mm]  kidney_length QTL population f 2wks N=144
Guay-Woodford1 10703 organ dimensions (none) kidney length normalized to body length   [ratio]  K_CR QTL population f 2wks N=144
Guay-Woodford1 10704 histopathology (none) renal cystic disease severity   [score]  severity QTL population f 2wks N=144

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Rencd  


Project / data set:   Guay-Woodford1     a.k.a. Guay-Woodford_2000
Excel file:   Data_Description_BALBxCAST_Guay-Woodford2000.xlsx
CSV file:   Guay-Woodford2000_BALBxCAST_B37_Data.csv
Readme / text file:   readme_Guay-Woodford2000.txt
QC plots, figures, etc.:   QCReport_Guay-Woodford2000.pdf