Gould1: Drug study: Antidepressant-like responses to lithium in males of 8 inbred mouse strains and 3 outbred stocks (2011)

Can A, Blackwell RA, Piantadosi SC, Dao DT, O'Donnell KC, Gould TD. Antidepressant-like responses to lithium in genetically diverse mouse strains. Genes Brain Behav. 2011 Jun;10(4):434-43. doi: 10.1111/j.1601-183X.2011.00682.x. Epub 2011 Mar 1.   PubMed 21306560     FullText


       
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Participants Adem Can       University of Maryland Baltimore, MD
Todd D Gould       University of Maryland Baltimore, MD
With: Blackwell RA, Piantadosi SC, Dao DT, O'Donnell KC
ContactTodd D Gould     tgould@psych.umaryland.edu     Lab web site
AcknowledgementsFunding provided by NIH MH084043
Project type Phenotype strain survey data set
MPD identifiersGould1     MPD:374
Data changelog No updates/corrections.       Initial release date: 07/2011.
Formatted citation
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Responses to lithium were assessed using the forced swim test (FST) based on the hypothesis that lithium-responsive mice are less prone to behavioral despair as demonstrated by sustained mobility during FST (immobility is associated with behavioral despair and depression). Following FST, blood and brain samples were collected to measure lithium concentration using flame photometry.

There were 4 treatment cohorts: saline control and acute administration of lithium 200, 300, and 400 mg/kg i.p.

Summary of procedures that were conducted
• forced swim test Lithium (several doses) vs. control. 6 min test.
• drug and metabolite quantification Lithium concentration in brain tissue and blood serum after lithium (several doses).
Mice: inbred   11 strains   ♂   age 7-8wks   4 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Gould1 37401 forced swim test lithium duration of immobility   [s]     lithium dose [mg/kg]:    0(saline)    200    300    400 inbred 11 m 7-8wks N=8
    Gould1 37405 drug and metabolite quantification lithium serum lithium concentration   [mmol/L]     lithium dose [mg/kg]:    200    300    400 inbred 11 m 7-8wks N=8
    Gould1 37408 drug and metabolite quantification lithium brain lithium concentration   [mmol/L]     lithium dose [mg/kg]:    200    300    400 inbred 11 m 7-8wks N=8
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