Gavras1: Diet effects: salt-induced changes in blood pressure and heart rate in 11 inbred strains of mice (2003)

Gavras H, Johns C, Paigen B, Peters LL

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Participants Haralambos Gavras       Boston University School of Medicine Boston, MA
Conrado Johns       Boston University Boston, MA
Beverly Paigen       The Jackson Laboratory Bar Harbor, ME
Luanne L Peters       The Jackson Laboratory Bar Harbor, ME
ContactHaralambos Gavras
AffiliationJackson Laboratory Heart, Lung, and Blood Center (HLB)
AcknowledgementsFunding provided by Program for Genomic Applications (PGA) NHLBI HL66611.

In fulfillment of NIH requirements that all information is made promptly and freely available to the research community, data are deposited in the MPD when complete.
Project type Phenotype strain survey data set
MPD identifiersGavras1     MPD:144
Data changelog No updates/corrections.       Initial release date: 02/2004.
Formatted citation
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An investigation of salt-induced hypertension. Animals were assessed for heart rate and systolic blood pressure using Visitech BP-2000 blood pressure analysis system, in two cohorts: 1) controls with only tap water to drink; 2) treated with 1% salt in drinking water for 2-wks. Each animal value is the average from multiple runs.

Summary of procedures that were conducted
• tail cuff Heart rate and blood pressure. Sodium chloride vs. control.
Mice: inbred   11 strains   ♀♂   age 9-12wks   2 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Gavras1 14401 tail cuff sodium chloride systolic blood pressure   [mmHg]     control    NaCl inbred 9 both 9-12wks N=6
    Gavras1 14403 tail cuff sodium chloride pulse rate   [n/min]     control    NaCl inbred 8 both 9-12wks N=7
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