Frankel1: Drug study: Induced seizures and their suppression with lamotrigine in 16 inbred strains of mice (2000)

Frankel WN, Taylor L, Beyer B, Tempel BL, White HS. Electroconvulsive thresholds of inbred mouse strains. Genomics. 2001 Jun 15;74(3):306-12.   PubMed 11414758  


       
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• Download Frankel1 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Wayne N Frankel       The Jackson Laboratory Bar Harbor, ME
H Steve White       University of Utah Salt Lake City, UT
With: Taylor L, Beyer B, Tempel BL
ContactWayne N Frankel     wnf@jax.org
AcknowledgementsFunding provided by NIH NS40246.
Project type Phenotype strain survey data set
MPD identifiersFrankel1     MPD:56
Data changelog 1 update/correction.       Initial release date: 05/2001.
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An electroconvulsive threshold test was applied to assess frontal and transcorneal induced seizures and their suppression with lamotrigene. For each strain/sex/measurement the following summary data were supplied: median value, N, and the 95% confidence interval. (In this project these median values are referred to as "means" in MPD data displays but they are really medians as described). Measurements for individual mice were not supplied. Assays were performed at two sites, Bar Harbor and Salt Lake City. Measurement descriptions use the following abbreviations:
"CC50" = Critical current (milli Amps) for 50% of the mice of a strain to reach seizure response (endpoint)
"CC97" = Critical current (milli Amps) for 97% of the mice of a strain to reach seizure response (endpoint)
"ED50" = Median effective dose (mg/kg)
"BH" = Assays performed in Bar Harbor
"SL" = Assays performed in Salt Lake City

Summary of procedures that were conducted
• electroconvulsion test Electroconvulsive thresholds. Lamotrigine. 2 test sites.
Mice: inbred   16 strains   ♀♂   age 6-11wks   3 cohorts

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Frankel1 5601 electroconvulsion test (none) median critical current (CC50) for minimal clonic seizure, frontal stimulation (at BH)   [mA]  E_MC_BH_FS inbred 4 m 6-11wks N=35
    Frankel1 5602 electroconvulsion test (none) median critical current (CC50), transcorneal stimulation (at BH)   [mA]  E_MC_BH_TC inbred 16 both 6-11wks N=33
    Frankel1 5603 electroconvulsion test (none) median critical current (CC50), transcorneal stimulation (at SL)   [mA]  E_MC_SL_TC inbred 7 both 6-11wks N=29
    Frankel1 5604 electroconvulsion test (none) median critical current (CC50) for maximal tonic hindlimb extension seizure, frontal stimulation (at BH)   [mA]  E_MT_BH_FS inbred 4 m 6-11wks N=44
    Frankel1 5605 electroconvulsion test (none) median critical current (CC50) for maximal tonic hindlimb extension seizure, transcorneal stimulation (at BH)   [mA]  E_MT_BH_TC inbred 16 both 6-11wks N=38
    Frankel1 5606 electroconvulsion test (none) median critical current (CC50) for maximal tonic hindlimb extension seizure, transcorneal stimulation (at SL)   [mA]  E_MT_SL_TC inbred 7 both 6-11wks N=29
    Frankel1 5607 electroconvulsion test (none) median critical current (CC50) for psychomotor seizure, frontal stimulation (at BH)   [mA]  E_PS_BH_FS inbred 4 m 6-11wks N=41
    Frankel1 5608 electroconvulsion test (none) median critical current (CC50) for psychomotor seizure, transcorneal stimulation (at BH)   [mA]  E_PS_BH_TC inbred 14 both 6-11wks N=41
    Frankel1 5609 electroconvulsion test (none) median critical current (CC50) for psychomotor seizure, transcorneal stimulation (at SL)   [mA]  E_PS_SL_TC inbred 7 both 6-11wks N=39
    Frankel1 5610 electroconvulsion test lamotrigine median effective dose (ED50) against minimal clonic seizures (CC97), transcorneal stimulation (at BH)   [mg/kg]  L_MC_BH_TC inbred 3 m 6-11wks N=63
    Frankel1 5612 electroconvulsion test lamotrigine median effective dose (ED50) against minimal clonic seizures (CC97), transcorneal stimulation (at SL)   [mg/kg]  L_MC_SL_TC inbred 3 m 6-11wks N=51
    Frankel1 5613 electroconvulsion test lamotrigine median effective dose (ED50) against maximal tonic hindlimb extension seizure (CC97), transcorneal stimulation (at BH)   [mg/kg]  L_MT_BH_TC inbred 3 m 6-11wks N=52
    Frankel1 5614 electroconvulsion test lamotrigine median effective dose (ED50) against maximal tonic hindlimb extension seizure (CC97), transcorneal stimulation (at SL)   [mg/kg]  L_MT_SL_TC inbred 3 m 6-11wks N=45
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