Feng1: Genetic analysis of blood pressure in 8 mouse intercross populations (2009)
Feng M, Deerhake ME, Keating R, Thaisz J, Xu L, Tsaih SW, Smith R, Ishige T, Sugiyama F, Churchill GA, DiPetrillo K. Genetic analysis of blood pressure in 8 mouse intercross populations.
Hypertension. 2009 Oct;54(4):802-9. Epub 2009 Aug 3.
Feng1 downloads
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QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Ontology terms mapped to Feng1 measures:
| Investigators |
M Feng Gary A Churchill The Jackson Laboratory, Bar Harbor, ME |
| Participants | Deerhake ME, Keating R, Thaisz J, Xu L, Tsaih SW, Smith R, Ishige T, Sugiyama F, DiPetrillo K |
| Contact | Gary A Churchill gary.churchill@jax.org |
| Affiliated Center | QTL Archive |
| Acknowledgements | Grants: This work was supported by the Novartis Institutes for BioMedical Research. |
| QTL Archive data set | |
| MPD identifiers | Feng1 MPD:216 |
| No updates/corrections. Initial release date: 08/2010. |
To study the genetic basis of hypertension (high blood pressure) and identify the genes that cause common forms of hypertension, eight F2 intercross with 2,577 male mice was generated to perform QTL analyses of blood pressure. The F2 population was produced from 14 inbred strains (129, A, D2, AKR, NZW, BTBR, SWR, C3H, KK, FVB, RIII, SJL, PL and CBA) and tail-cuff blood pressure was measured when mice were 8 weeks old. For detailed protocols see Feng et al 2009.
| Cross 1: 129S1/SvImJ x A/J Feng1 | |
| Progenitor strains | 129S1/SvImJ A/J |
| Cross direction notation | (129xA) F1 x (129xA) F1 |
| Cross type | F2 intercross |
| Population size | 0 ♀ 336 ♂ |
| Age | 8wks |
| Progenitor strains | 129S1/SvImJ DBA/2J |
| Cross type | None |
| Population size | None ♀ None ♂ |
| Age | 8wks |
| Progenitor strains | AKR/J NZW/LacJ |
| Cross type | None |
| Population size | None ♀ None ♂ |
| Age | 8wks |
| Progenitor strains | BTBR T+ Itpr3tf/J SWR/J |
| Cross type | None |
| Population size | None ♀ None ♂ |
| Age | 8wks |
| Progenitor strains | C3H/HeJ KK/HlJ |
| Cross type | None |
| Population size | None ♀ None ♂ |
| Age | 8wks |
| Progenitor strains | FVB/NJ RIIIS/J |
| Cross type | None |
| Population size | None ♀ None ♂ |
| Age | 8wks |
| Progenitor strains | CBA/J PL/J |
| Cross type | None |
| Population size | None ♀ None ♂ |
| Age | 8wks |
| Progenitor strains | RIIIS/J SJL/J |
| Cross type | None |
| Population size | None ♀ None ♂ |
| Age | 8wks |
Data set |
Procedure / Protocol |
Treatment |
Phenotype Measure / Variable (click to view) |
Panel |
No. of Strains |
Sex |
Age |
Sample Size (Avg)
|
||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| tail cuff | (none) | systolic blood pressure [mm/Hg] SBP 21601 | QTL population | m | N=336 | |||||||
| tail cuff | (none) | diastolic blood pressure [mm/Hg] DBP 21602 | QTL population | m | N=336 | |||||||
| organ weights | (none) | left kidney weight [g] LKW 21603 | QTL population | m | N=336 | |||||||
| organ weights | (none) | right kidney weight [g] RKW 21604 | QTL population | m | N=336 | |||||||
| body weight | (none) | body weight [g] BW 21605 | QTL population | m | N=336 | |||||||
Cross 1: 129S1/SvImJ x A/J Feng1 a.k.a. Feng_2009a
Excel file: Data_Description_129xAJ_Feng2009.xlsx
CSV file: Feng2009_129xAJ_B37_Data.csv
Readme / text file: readme_Feng2009a.txt
QC plots, figures, etc.: QCReport_Feng2009a.pdf
Project / data set: Feng1b a.k.a. None
Project / data set: Feng1c a.k.a. None
Project / data set: Feng1d a.k.a. None
Project / data set: Feng1e a.k.a. None
Project / data set: Feng1f a.k.a. None
Project / data set: Feng1g a.k.a. None
Project / data set: Feng1h a.k.a. None