Feng1: Genetic analysis of blood pressure in 8 mouse intercross populations (2009)

Feng M, Deerhake ME, Keating R, Thaisz J, Xu L, Tsaih SW, Smith R, Ishige T, Sugiyama F, Churchill GA, DiPetrillo K. Genetic analysis of blood pressure in 8 mouse intercross populations. Hypertension. 2009 Oct;54(4):802-9. Epub 2009 Aug 3.   PubMed 19652078  


     
Feng1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Participants M Feng
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Deerhake ME, Keating R, Thaisz J, Xu L, Tsaih SW, Smith R, Ishige T, Sugiyama F, DiPetrillo K
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsGrants: This work was supported by the Novartis Institutes for BioMedical Research.
Project type QTL Archive data set
MPD identifiersFeng1     MPD:216
Data changelog No updates/corrections.       Initial release date: 08/2010.
To study the genetic basis of hypertension (high blood pressure) and identify the genes that cause common forms of hypertension, eight F2 intercross with 2,577 male mice was generated to perform QTL analyses of blood pressure. The F2 population was produced from 14 inbred strains (129, A, D2, AKR, NZW, BTBR, SWR, C3H, KK, FVB, RIII, SJL, PL and CBA) and tail-cuff blood pressure was measured when mice were 8 weeks old. For detailed protocols see Feng et al 2009.


QTL data set parameters:
Cross 1: 129S1/SvImJ x A/J       Feng1
Progenitor strains 129S1/SvImJ     A/J    
Cross direction notation(129xA) F1 x (129xA) F1
Cross typeF2 intercross
Population size 0 ♀     336 ♂
Age8wks

Cross 2: 129S1/SvImJ x DBA2/J       Feng1b
Progenitor strains 129S1/SvImJ     DBA/2J    
Cross direction notation(129xDBA2) F1 x (129xDBA2) F1
Cross typeF2 intercross
Population size 0 ♀     324 ♂
Age8wks

Cross 3: AKR/J x NZW/LacJ       Feng1c
Progenitor strains AKR/J     NZW/LacJ    
Cross direction notation(AKRxNZW) F1 x (AKRxNZW) F1
Cross typeF2 intercross
Population size 0 ♀     334 ♂
Age8wks

Cross 4: BTBR T+ tf/J x SWR/J       Feng1d
Progenitor strains BTBR T+ Itpr3tf/J     SWR/J    
Cross direction notation(BTBRxSWR) F1 x (BTBRxSWR) F1
Cross typeF2 intercross
Population size 0 ♀     336 ♂
Age8wks

Cross 5: C3H/HeJ x KK/HlJ       Feng1e
Progenitor strains C3H/HeJ     KK/HlJ    
Cross direction notation(C3HxKK) F1 x (C3HxKK) F1
Cross typeF2 intercross
Population size 0 ♀     335 ♂
Age8wks

Cross 6: FVB/NJ x RIIIS/J       Feng1f
Progenitor strains FVB/NJ     RIIIS/J    
Cross direction notation(FVBxRIII) F1 x (FVBxRIII) F1
Cross typeF2 intercross
Population size 0 ♀     252 ♂
Age8wks

Cross 7: PL/J x CBA/J       Feng1g
Progenitor strains CBA/J     PL/J    
Cross direction notation(PLxCBA) F1 x (PLxCBA) F1
Cross typeF2 intercross
Population size 0 ♀     324 ♂
Age8wks

Cross 8: SJL/J x RIIIS/J       Feng1h
Progenitor strains RIIIS/J     SJL/J    
Cross direction notation(SJLxRIII) F1 x (SJLxRIII) F1
Cross typeF2 intercross
Population size 0 ♀     336 ♂
Age8wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Feng1 21601 tail cuff (none) systolic blood pressure   [mm/Hg]  SBP QTL population m 8wks N=336
Feng1 21602 tail cuff (none) diastolic blood pressure   [mm/Hg]  DBP QTL population m 8wks N=336
Feng1 21603 organ weights (none) left kidney weight   [g]  LKW QTL population m 8wks N=336
Feng1 21604 organ weights (none) right kidney weight   [g]  RKW QTL population m 8wks N=336
Feng1 21605 body weight (none) body weight   [g]  BW QTL population m 8wks N=336

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Bpq14   Bpq15   Bpq16   Bpq17   Bpq18   Bpq19   Bpq20   Bpq24   Bpq25   Bpq26   Bpq27   Bpq28   Bpq29   Bpq30  


Cross 1: 129S1/SvImJ x A/J     Feng1     a.k.a. Feng_2009a
Excel file:   Data_Description_129xAJ_Feng2009.xlsx
CSV file:   Feng2009_129xAJ_B37_Data.csv
Readme / text file:   readme_Feng2009a.txt
QC plots, figures, etc.:   QCReport_Feng2009a.pdf

Cross 2: 129S1/SvImJ x DBA2/J     Feng1b     a.k.a. Feng_2009b
Excel file:   Data_Description_129xDBA2_Feng2009.xlsx
CSV file:   Feng2009_129xD2_B37_Data.csv
Readme / text file:   readme_Feng2009b.txt
QC plots, figures, etc.:   QCReport_Feng2009b.pdf

Cross 3: AKR/J x NZW/LacJ     Feng1c     a.k.a. Feng_2009c
Excel file:   Data_Description_AKRxNZW_Feng2009.xlsx
CSV file:   Feng2009_AKRxNZW_B37_Data.csv
Readme / text file:   readme_Feng2009c.txt
QC plots, figures, etc.:   QCReport_Feng2009c.pdf

Cross 4: BTBR T+ tf/J x SWR/J     Feng1d     a.k.a. Feng_2009d
Excel file:   Data_Description_BTBRxSWR_Feng2009.xlsx
CSV file:   Feng2009_BTBRxSWR_B37_Data.csv
Readme / text file:   readme_Feng2009d.txt
QC plots, figures, etc.:   QCReport_Feng2009d.pdf

Cross 5: C3H/HeJ x KK/HlJ     Feng1e     a.k.a. Feng_2009e
Excel file:   Data_Description_C3HxKK_Feng2009.xlsx
CSV file:   Feng2009_C3HxKK_B37_Data.csv
Readme / text file:   readme_Feng2009e.txt
QC plots, figures, etc.:   QCReport_Feng2009e.pdf

Cross 6: FVB/NJ x RIIIS/J     Feng1f     a.k.a. Feng_2009f
Excel file:   Data_Description_FVBxRIII_Feng2009.xlsx
CSV file:   Feng2009_FVBxRIII_B37_Data.csv
Readme / text file:   readme_Feng2009f.txt
QC plots, figures, etc.:   QCReport_Feng2009f.pdf

Cross 7: PL/J x CBA/J     Feng1g     a.k.a. Feng_2009g
Excel file:   Data_Description_PLxCBA_Feng2009.xlsx
CSV file:   Feng2009_PLxCBA_B37_Data.csv
Readme / text file:   readme_Feng2009g.txt
QC plots, figures, etc.:   QCReport_Feng2009g.pdf

Cross 8: SJL/J x RIIIS/J     Feng1h     a.k.a. Feng_2009h
Excel file:   Data_Description_SJLxRIII_Feng2009.xlsx
CSV file:   Feng2009_SJLxRIII_B37_Data.csv
Readme / text file:   readme_Feng2009h.txt
QC plots, figures, etc.:   QCReport_Feng2009h.pdf