Dorward1: Ovarian granulosa cell tumors in F2 progeny from the CAST/EiJ x SWXJ9/BmJ intercross (2005)

Dorward AM, Shultz KL, Horton LG, Li R, Churchill GA, Beamer WG. Distal Chr 4 harbors a genetic locus (Gct1) fundamental for spontaneous ovarian granulosa cell tumorigenesis in a mouse model. Cancer Res. 2005 Feb 15;65(4):1259-64.   PubMed 15735010  

Dorward1 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Participants A M Dorward
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Shultz KL, Horton LG, Li R, Beamer WG
ContactGary A Churchill
AffiliationChurchill Group QTL Archive
AcknowledgementsCancer Research Foundation of America fellowship (A.M. Dorward); Maine Cancer Foundation grant (A.M. Dorward); American Institute for Cancer Research grant (W.G. Beamer); NIH grants CA88327 (G.A. Churchill and R. Li), AR43618 (W.G. Beamer and L.G. Horton); and Strawbridge Foundation and National Cancer Institute Cancer Core grant CA34196 (The Jackson Laboratory).
Project type QTL Archive data set
MPD identifiersDorward1     MPD:163
Data changelog No updates/corrections.       Initial release date: 10/2009.
An intercross of the SWXJ9/BmJ recombinant inbred strain and CAST/EiJ was generated to identify QTLs affecting ovarian granulosa cell tumors. For detailed information see Dorward et al 2005.

QTL data set parameters:
Progenitor strains CAST/EiJ     SWXJ9/BmJ    
Cross direction notation(CASTxSWXJ9) F1 x SWXJ9
Cross typeN2F1 backcross
Population size 162 ♀     0 ♂

Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Dorward1 16301 histopathology (none) presence of ovarian granulosa cell tumor (0=normal 1=tumor)   [designation]  GC-tumor QTL population f 8wks N=162

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Gct1   Gct7   Gct8   Gct9  

Project / data set:   Dorward1     a.k.a. Dorward_2005
Excel file:   Data_Description_CASTxSWXJ_Dorward2005.xlsx
CSV file:   Dorward2005_CASTxSWXJ_BC_B37_Data.csv
Readme / text file:   readme_Dorward2005.txt
QC plots, figures, etc.:   QCReport_Dorward2005.pdf