Doorenbos1: Albuminuria QTL in the presence and absence of Apoe in 2 F2 intercross crosses (2008)

Doorenbos C, Tsaih SW, Sheehan S, Ishimori N, Navis G, Churchill G, Dipetrillo K, Korstanje R. Quantitative trait loci for urinary albumin in crosses between C57BL/6J and A/J inbred mice in the presence and absence of Apoe. Genetics. 2008 May;179(1):693-9.   PubMed 18493081  


     
Doorenbos1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Participants C Doorenbos
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Tsaih SW, Sheehan S, Ishimori N, Navis G, Dipetrillo K, Korstanje R
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsThis work was supported by National Institute of Diabetes and Digestive and Kidney Diseases grant DK-69381 and National Institute of General Medical Sciences grant GM-070683.
Project type QTL Archive data set
MPD identifiersDoorenbos1     MPD:208
Data changelog No updates/corrections.       Initial release date: 10/2009.
This project is to identify the genetic loci that control albuminuria in mouse crosses in the presence and abscence of Apoe. For detailed protocols see Doorenbos et al 2008.


QTL data set parameters:
Cross 1: B6 and A/J       Doorenbos1
Progenitor strains A/J     C57BL/6J    
Cross direction notation(B6xA) F1 x (B6xA) F1
Cross typeF2 intercross
Population size 0 ♀     383 ♂
Age8-10wks

Cross 2: A/J and B6.Apoe-/-       Doorenbos1b
Progenitor strains A/J     C57BL/6J.Apoe-/-    
Cross direction notation(AxB) F1 x (AxB) F1
Cross typeF2 intercross
Population size 0 ♀     207 ♂
Age8-10wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Doorenbos1 20801 urinalysis (none) urinary creatinine   [mg/dL]  UCreat QTL population m 8-10wks N=383
Doorenbos1 20802 urinalysis (none) microalbumin   [mg/dL]  Microalb QTL population m 8-10wks N=383
Doorenbos1 20803 urinalysis (none) albumin/creatinine ratio   [mg/g]  Alb/Creat QTL population m 8-10wks N=383
Doorenbos1 20804 body weight (none) Body Weight   [g]  BW QTL population m 8-10wks N=383

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Albq1   Albq2   Albq3   Albq4  


Cross 1: B6 and A/J     Doorenbos1     a.k.a. Doorenbos_2008a
Excel file:   Data_Description_BxA_Doorenbos2008a.xlsx
CSV file:   Doorenbos2008a_BxA_B37_Data.csv
Readme / text file:   readme_Doorenbos2008a.txt
QC plots, figures, etc.:   QCReport_Doorenbos2008a.pdf

Cross 2: A/J and B6.Apoe-/-     Doorenbos1b     a.k.a. Doorenbos_2008b
Excel file:   Data_Description_AxBApoe_Doorenbos2008b.xlsx
CSV file:   Doorenbos2008b_AxBApoe_B37_Data.csv
Readme / text file:   readme_Doorenbos2008b.txt
QC plots, figures, etc.:   QCReport_Doorenbos2008b.pdf