Dickson1: Incentive salience to reward cues measured by Pavlovian sign-tracking in 5 inbred founder strains of the Collaborative Cross (2015)

Dickson PE, McNaughton KA, Hou L, Anderson LC, Long KH, Chesler EJ. Sex and strain influence attribution of incentive salience to reward cues in mice. Behav Brain Res. 2015 Oct 1;292:305-15. doi: 10.1016/j.bbr.2015.05.039. Epub 2015 Jun 20.   PubMed 26102561     FullText

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Participants Price E Dickson       The Jackson Laboratory Bar Harbor, ME
Elissa J Chesler       The Jackson Laboratory Bar Harbor, ME
With: McNaughton KA, Hou L, Anderson LC, Long KH
ContactPrice E Dickson     price.dickson@jax.org
AcknowledgementsFunding provided by NIH DA37927, GM76468; Research Experience for Undergraduates at The Jackson Laboratory (DBI-1262049)
Project type Phenotype strain survey data set
MPD identifiersDickson1     MPD:546
Data changelog No updates/corrections.       Initial release date: 06/2016.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
Sign-tracking and the related phenotype goal-tracking were evaluated under paired and unpaired conditions. The propensity to attribute incentive salience to reward cues, measured by Pavlovian sign-tracking, has been shown previously to be strongly associated with addiction-related traits including cocaine self-administration, impulsivity, novelty reactivity, and novelty preference. The means of sign-tracking and goal-tracking duration have been accessioned for mice under paired and unpaired conditions. The remaining measurements are available in a supplemental download file and are summarized graphically here. A correlations matrix of most measurements is also available.

Summary of procedures that were conducted
• operant conditioning chamber Sign tracking and goal tracking paradigm with Pavlovian conditioned approach.
Mice: inbred   5 strains   ♀♂   age 12-20wks   2 cohorts

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Dickson1 54601 operant conditioning chamber (none) goal-tracking   [s]     unpaired    paired inbred 5 both 12-20wks N=5
    Dickson1 54611 operant conditioning chamber (none) sign-tracking   [s]     unpaired    paired inbred 5 both 12-20wks N=5
    All boxes