Davidson1: Exencephaly research in BALB/cJ x FVB/NJ reciprocal backcross (2007)

Davidson CE, Li Q, Churchill GA, Osborne LR, McDermid HE. Modifier locus for exencephaly in Cecr2 mutant mice is syntenic to the 10q25.3 region associated with neural tube defects in humans. Physiol Genomics. 2007 Oct 22;31(2):244-5Epub 2007 Jul 10.   PubMed 17623803  

Davidson1 downloads
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Participants C E Davidson
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Li Q, Osborne LR, McDermid HE
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsThis work was supported by Canadian Institutes of Health Research (CIHR) Grant MOP64361 and grants from the Stollery Children’s Hospital Foundation and the Spina Bifida and Hydrocephalus Association of Northern Alberta. C. E. Davidson was supported by a scholarship from the Natural Sciences and Engineering Research Council of Canada. Q. Li and G. A. Churchill are supported on GM070683.
Project type QTL Archive data set
MPD identifiersDavidson1     MPD:192
Data changelog No updates/corrections.       Initial release date: 08/2010.
To study the genetic and environmental causes of exencephaly (neural tube defect (NTD)), a backcross between strain BALB/c and FVB/N was generated to identify the major genetic modifier of this birth defect. 128 mouse embryos were measured for NTDs and given the scores based on that. The scores were analyzed and the result showed the major modifier of NTDs was on chromosome 19. For detailed protocols see Davidson et al 2007.

QTL data set parameters:
Progenitor strains BALB/cJ     FVB/NJ    
Cross direction notationBALB x (FVB x BALB); BALB x (BALB x FVB); (FVB x BALB) x BALB
Cross typeBackcross
Population size 106 ♀     82 ♂

Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Davidson1 19201 health assessment (none) 0=exencephaly, 1=normal   [score]  Exencephaly QTL population both embryo N=94
Davidson1 19202 health assessment (none) 1=exencephaly, 0=normal   [score]  Exen2 QTL population both embryo N=94

Project / data set:   Davidson1     a.k.a. Davidson_2007
Excel file:   Data_Description_BalbxFVB_Davidson2007.xlsx
CSV file:   Davidson2007_BalbxFVB_B37_Data.csv
Readme / text file:   readme_Davidson2007.txt
QC plots, figures, etc.:   QCReport_Davidson2007.pdf