Clemens1: UV-induced immunosuppression in backcross mice (involving BALB/cAnNCrl and C57BL/6NCrl) (2000)

Clemens KE, Churchill G, Bhatt N, Richardson K, Noonan FP. Genetic control of susceptibility to UV-induced immunosuppression by interacting quantitative trait loci. Genes Immun. 2000;1(4):251-9.   PubMed 11196701  


     
Clemens1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Participants K E Clemens
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Bhatt N, Richardson K, Noonan FP
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsThese studies were funded by NIH RO1CA53765 to FPN.
Project type QTL Archive data set
MPD identifiersClemens1     MPD:106
Data changelog No updates/corrections.       Initial release date: 01/2008.
A backcross involving BALB/cAnNCrl and C57BL/6NCrl inbred mouse strains was generated to identify QTLs involved in UV-induced immunosuppression. Backcross progeny were tested for systemic immunosuppression of a contact hypersensitivity response. Intervention: UV radiation dose 4.5 kJ/m2 for 15 min. Sensitization: trinitrochlorobenzene (TNCB). For detailed protocols see Clemens et al 2000.


QTL data set parameters:
Progenitor strains BALB/cAnNCrl     C57BL/6NCrl    
Cross direction notationBALB x (BALBxB6)
Cross typeBackcross
Population size 75 ♀     59 ♂
Age9-30wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Clemens1 10601 health assessment ultraviolet light UV-induced immunosuppression of contact hypersensitivity   [%]  suppression QTL population both 9-30wks N=67

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Uvbi1   Uvbi2  


Project / data set:   Clemens1     a.k.a. Clemens_2000
Excel file:   Data_Description_BALBxB6_Clemens2000.xlsx
CSV file:   Clemens2000_BALBxB6_B37_Data.csv
Readme / text file:   readme_Clemens2000.txt
QC plots, figures, etc.:   QCReport_Clemens2000.pdf