Brich1: Mapping of genetic loci that modify tau hyperphosphorylation in F2 progeny of BALB/cByJ x C57BL/6J intercross (2003)

Brich J, Shie FS, Howell BW, Li R, Tus K, Wakeland EK, Jin LW, Mumby M, Churchill G, Herz J, Cooper JA. Genetic modulation of tau phosphorylation in the mouse. J Neurosci. 2003 Jan 1;23(1):187-92.   PubMed 12514215  

Brich1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Participants J Brich
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Shie FS, Howell BW, Li R, Tus K, Wakeland EK, Jin LW, Mumby M, Herz J, Cooper JA
ContactGary A Churchill
AffiliationChurchill Group QTL Archive
Project type QTL Archive data set
MPD identifiersBrich1     MPD:128
Data changelog No updates/corrections.       Initial release date: 07/2011.
To study the relationship between protein tau (the axonal microtubule stabilizing protein) and Dab1 (a cytoplasmic adapter protein), a Dab1-deficient intercross between BALB/cByJ and C57BL/6J was generated to identify the QTLs that modulate tau phosphorylation. Only the Dab1-/- homozygous mice were tested for tau phosphorylation level. For detailed protocols, see Brich et al 2003.

QTL data set parameters:
Progenitor strains BALB/cByJ     C57BL/6J    
Cross direction notation(BALB x B6) F1 x (BALB x B6) F1
Cross typeF2 intercross
Population size 51 ♀     0 ♂
Notessex not specified, arbitrarily set to female

Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Brich1 12801 metabolite quantification (none) tau phosphorylation level   [score]  level QTL population f 3wks N=51

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:

Project / data set:   Brich1     a.k.a. Brich_2003
Excel file:   Data_Description_BALBxB6_Brich2003.xlsx
CSV file:   Brich2003_BALBxB6_B37_Data.csv
Readme / text file:   readme_Brich2003.txt
QC plots, figures, etc.:   QCReport_Brich2003.pdf