Benoist1: Survey of regulatory T cells (Treg) of the thymus and spleen in males of 33 inbred strains of mice (2007)

Feuerer M, Jiang W, Holler PD, Satpathy A, Campbell C, Bogue M, Mathis D, Benoist C. Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18181-6. Epub 2007 Nov 8.   PubMed 17991775     FullText


       
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• Download Benoist1 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Christophe Benoist       Harvard Medical School Boston, MA
Diane Mathis       Harvard Medical School Boston, MA
Ansuman Satpathy       Washington University School of Medicine St. Louis, MO
Markus Feuerer       Harvard Medical School Boston, MA
With: Jiang W, Holler P, Campbell C
ContactChristophe Benoist     Christophe_Benoist@hms.harvard.edu     Lab web site
AffiliationImmunological Genome Project
AcknowledgementsFunding provided by NIH DK60027; German Research Foundation; Juvenile Diabetes Research Foundation 4-2004-368

Mice provided by the Mouse Phenome Project Collaborations Program, The Jackson Laboratory.

Acknowledgements: Technical assistance by Roser L, Hyatt E, Hattori K, LaVecchio J, Buruzala G.
Project type Phenotype strain survey data set
MPD identifiersBenoist1     MPD:258
Data changelog 1 update/correction.       Initial release date: 11/2008.
Formatted citation
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An investigation of strain differences in the production of regulatory T cells in thymus and spleen using flow cytometry.

Summary of procedures that were conducted
• immune cell quantification Regulatory T cells (Treg), thymus, spleen.
Mice: inbred   33 strains   ♂   age 5-6wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Benoist1 25801 immune cell quantification (none) percent of thymic CD4 Treg cells that are CD25hi   [%]  Treg_thy_CD25 inbred 33 m 5-6wks N=3
    Benoist1 25802 immune cell quantification (none) percent of thymic CD4 Treg cells that are Foxp3+   [%]  Treg_thy_Foxp3 inbred 10 m 5-6wks N=3
    Benoist1 25803 immune cell quantification (none) percent of splenic CD4 Treg cells that are CD25hi   [%]  Treg_spl_CD25 inbred 31 m 5-6wks N=3
    Benoist1 25804 immune cell quantification (none) percent of splenic CD4 Treg cells that are Foxp3+   [%]  Treg_spl_Foxp3 inbred 10 m 5-6wks N=3
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