Beamer2: Bone mineral density and IGF-1 levels in F2 progeny from a C57BL/6J x C3H/HeJ intercross (2001)

Beamer WG   With: Shultz KL, Donahue LR, Churchill GA, Sen S, Wergedal JR, Baylink DJ, Rosen CJ

     
Beamer2 downloads
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Participants Wesley G Beamer       The Jackson Laboratory Bar Harbor, ME
With: Shultz KL, Donahue LR, Churchill GA, Sen S, Wergedal JR, Baylink DJ, Rosen CJ
ContactWesley G Beamer     wgb@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsFunding provided by NIH AR43618, AR45433, CA34196; and the U.S. Army (DAMD17-96-1-6306)
Project type QTL Archive data set
MPD identifiersBeamer2     MPD:112
Data changelog No updates/corrections.       Initial release date: 01/2008.
An intercross of C3H/HeJ and C57BL/6J was generated to identify quantitative trait loci for serum insulin-like growth factor-1 (IGF-1) levels and bone-related phenotypes. F2 females were tested for IGF-1 and analyzed for femur bone mineral density (BMD), strength, and geometry. For detailed protocols see Beamer et al 2001 and Rosen et al 2000.


QTL data set parameters:
Progenitor strains C3H/HeJ     C57BL/6J    
Cross direction notation(B6xC3H) F1 x (B6xC3H) F1
Cross typeF2 intercross
Population size 999 ♀     0 ♂
Age16wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Beamer2 11201 body weight (none) body weight   [g]  bw QTL population f 16wks N=999
Beamer2 11202 hormone quantification (none) insulin-like growth factor 1 (serum IGF-1), normalized   [ng/mL]  IGF1_adj QTL population f 16wks N=999
Beamer2 11203 DXA (none) femur, cortical shell volumetric bone mineral density   [mg/mm3]  femur_cort_BMD QTL population f 16wks N=999
Beamer2 11204 DXA (none) femur, total bone mineral density   [mg/mm3]  femur_tot_BMD QTL population f 16wks N=999
Beamer2 11205 DXA (none) femur, total volumetric bone mineral density   [g/cm3]  femur_tot_vBMD QTL population f 16wks N=999
Beamer2 11206 computed tomography (none) femur, average bone volume (total, mid-diaphysis)   [g/cm3]  femur_mid_tot_vol QTL population f 16wks N=999
Beamer2 11207 computed tomography (none) femur, average cortical bone volume (mid-diaphysis)   [g/cm3]  femur_mid_cort_vol QTL population f 16wks N=999
Beamer2 11208 computed tomography (none) femur, percent of total volume that is cortical bone   [%]  femur_pct_cort QTL population f 16wks N=999
Beamer2 11209 computed tomography (none) femur, surface area to tissue volume (index)   [ratio]  femur_ratio QTL population f 16wks N=999
Beamer2 11210 computed tomography (none) femur, length (condyles to rostral tip of greater trochanter)   [mm]  femur_length QTL population f 16wks N=999
Beamer2 11211 computed tomography (none) femur, average cortical thickness (mid-diaphysis)   [mm]  femur_thickness QTL population f 16wks N=999
Beamer2 11212 computed tomography (none) femur, medial to lateral width (mid-diaphysis)   [mm]  femur_ML QTL population f 16wks N=999
Beamer2 11213 computed tomography (none) femur, anterior to posterior (rostral to caudal) width (mid-diaphysis)   [mm]  femur_AP QTL population f 16wks N=999
Beamer2 11214 computed tomography (none) femur, ratio of medial-lateral (ML) to anterior-posterior (AP)   [ratio]  femur_ML_AP QTL population f 16wks N=999
Beamer2 11215 biomechanical test (none) femur, ultimate load   [Ng/mL]  femur_load QTL population f 16wks N=999
Beamer2 11216 biomechanical test (none) femur, energy to failure   [N⋅mm]  femur_energy QTL population f 16wks N=999
Beamer2 11217 biomechanical test (none) femur, stiffness   [N⋅mm]  femur_stiffness QTL population f 16wks N=999
Beamer2 11218 biomechanical test (none) femur, cross-sectional moment of inertia   [mm4]  femur_inertia QTL population f 16wks N=999
Beamer2 11219 biomechanical test (none) femur, ultimate stress   [N]  femur_stress QTL population f 16wks N=999
Beamer2 11220 biomechanical test (none) femur, elastic modulus (toughness)   [N/mm2]  femur_tough QTL population f 16wks N=999
Beamer2 11221 biomechanical test (none) femur, load at specimen failure (break point)   [N]  femur_break QTL population f 16wks N=999
Beamer2 11222 computed tomography (none) trabecular bone, surface area to volume (ratio)   [ratio]  trab_ratio QTL population f 16wks N=999
Beamer2 11223 computed tomography (none) trabecular bone, average thickness   [mm]  trab_thickness QTL population f 16wks N=999
Beamer2 11224 computed tomography (none) trabecular bone, average number   [n]  trab_number QTL population f 16wks N=999
Beamer2 11225 computed tomography (none) trabecular bone, average spacing   [mm]  trab_spacing QTL population f 16wks N=999
To see more rows use the paging control at top.

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Bmd10   Bmd11   Bmd12   Bmd13   Bmd14   Bmd15   Bmd16   Bmd5   Bmd6   Bmd7   Bmd8   Bmd9   Igf1sl1   Igf1sl2   Igf1sl3   Igf1sl4   Vtbt1   Vtbt10   Vtbt11   Vtbt12   Vtbt13   Vtbt14   Vtbt15   Vtbt16   Vtbt17   Vtbt18   Vtbt19   Vtbt2   Vtbt3   Vtbt4   Vtbt5   Vtbt6   Vtbt7   Vtbt8   Vtbt9  


Project / data set:   Beamer2     a.k.a. Beamer_2001
Excel file:   Data_Description_B6xC3H_Beamer2001.xlsx
CSV file:   Beamer2001_B6xC3H_B37_Data.csv
Readme / text file:   readme_Beamer2001txt.txt
QC plots, figures, etc.:   QCReport_Beamer2001.pdf


References   (chronological)

1.   Rosen CJ, Churchill GA, Donahue LR, Shultz KL, Burgess JK, Powell DR, Ackert C, Beamer WG. Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice. Bone. 2000 Oct;27(4):521-8.   PubMed 11033447  

2.   Beamer WG, Shultz KL, Donahue LR, Churchill GA, Sen S, Wergedal JR, Baylink DJ, Rosen CJ. Quantitative trait loci for femoral and lumbar vertebral bone mineral density in C57BL/6J and C3H/HeJ inbred strains of mice. J Bone Miner Res. 2001 Jul;16(7):1195-206.   PubMed 11450694  

3.   Bouxsein ML, Uchiyama T, Rosen CJ, Shultz KL, Donahue LR, Turner CH, Sen S, Churchill GA, Muller R, Beamer WG. Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice. J Bone Miner Res. 2004 Apr;19(4):587-99. Epub 2003 Dec 22.   PubMed 15005846  

4.   Ackert-Bicknell CL, Karasik D, Li Q, Smith RV, Hsu YH, Churchill GA, Paigen BJ, Tsaih SW. Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map. J Bone Miner Res. 2010 Aug;25(8):1808-20.   PubMed 20200990