Beamer1: Bone mineral density in F2 progeny from a C57BL/6J x CAST/EiJ intercross (1999)

Beamer WG, Shultz KL, Churchill GA, Frankel WN, Baylink DJ, Rosen CJ, Donahue LR. Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice. Mamm Genome. 1999 Nov;10(11):1043-9.   PubMed 10556421  

Ackert-Bicknell CL, Karasik D, Li Q, Smith RV, Hsu YH, Churchill GA, Paigen BJ, Tsaih SW. Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map. J Bone Miner Res. 2010 Aug;25(8):1808-20.   PubMed 20200990  


     
Beamer1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Participants Wesley G Beamer       The Jackson Laboratory Bar Harbor, ME
With: Shultz KL, Frankel WN, Baylink DJ, Rosen CJ, Donahue LR, Ackert-Bicknell CL, Karasik D, Li Q, Smith RV, Hsu YH, Churchill GA, Paigen BJ, Tsaih SW
ContactWesley G Beamer     wgb@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsFunding provided by NIH AR43618, RR08911, CA34196; US Army (DAMA17-94-J-4016) and the SD Bechtel Foundation
Project type QTL Archive data set
MPD identifiersBeamer1     MPD:105
Data changelog No updates/corrections.       Initial release date: 01/2008.
An intercross of C57BL/6J and CAST/EiJ was generated to identify QTLs for bone mineral density. F2 females were tested for femoral density. For detailed protocols see Beamer et al 1999.


QTL data set parameters:
Progenitor strains C57BL/6J     CAST/EiJ    
Cross direction notation(B6xCAST) F1 x (B6xCAST) F1
Cross typeF2 intercross
Population size 711 ♀     0 ♂
Age20wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Beamer1 10501 computed tomography (none) femur, average bone volume (total, mid diaphysis)   [g/cm3]  femur_mid_cort_vol QTL population f 20wks N=711
Beamer1 10502 computed tomography (none) femur, average cortical bone volume (mid-diaphysis)   [g/cm3]  femur_mid_tot_vol QTL population f 20wks N=711

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Bmd1   Bmd2   Bmd3   Bmd4  


Project / data set:   Beamer1     a.k.a. Beamer_1999
Excel file:   Data_Description_B6xCAST_Beamer1999.xlsx
CSV file:   Beamer1999_B6xCAST_B37_Data.csv
Readme / text file:   readme_Beamer1999.txt
QC plots, figures, etc.:   QCReport_Beamer1999.pdf