Bailey1: Identification of QTL for locomotor activation and anxiety using related inbred strains C57BL/6J and C58/J (2008)

Bailey JS, Grabowski-Boase L, Steffy BM, Wiltshire T, Churchill GA, Tarantino LM. Identification of quantitative trait loci for locomotor activation and anxiety using closely related inbred strains. Genes Brain Behav. 2008 Oct;7(7):761-9.   PubMed 19130624  


     
Bailey1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.
Participants J S Bailey
Gary A Churchill       The Jackson Laboratory Bar Harbor, ME
With: Grabowski-Boase L, Steffy BM, Wiltshire T, Tarantino LM
ContactGary A Churchill     gary.churchill@jax.org
AffiliationChurchill Group QTL Archive
AcknowledgementsResearch described in this article was supported by a Novartis Grant SFP-1407 and funding from the NIH NIDA Grant DA 022392 to L.M.T.
Project type QTL Archive data set
MPD identifiersBailey1     MPD:207
Data changelog No updates/corrections.       Initial release date: 10/2009.
An intercross of similar inbred mouse strains, C57BL/6J and C58/J, was carried out as a control cross for a mutagenesis mapping study in behavior research. The authors identified significant QTL in F2 progeny. The locus on Chr 8 and its interaction effect form the core set of QTL controlling activation and anxiety behaviors, with additional loci on Chr 1 and 6 present in a subset of the behaviors. Mice were assessed using the open field test.


QTL data set parameters:
Progenitor strains C57BL/6J     C58/J    
Cross direction notation(B6xC58/J) F1 x (B6xC58/J) F1
Cross typeF2 intercross
Population size 196 ♀     166 ♂
Age8wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
Bailey1 20701 open field test (none) percent time spent in center of arena (interval of 10 min)   [%]  PCTT10 QTL population both 8wks N=181
Bailey1 20702 open field test (none) total distance   [cm]  TOTDIST QTL population both 8wks N=181
Bailey1 20703 open field test (none) total rearing   [n]  TOTREAR QTL population both 8wks N=181
Bailey1 20704 open field test (none) ambulatory episodes   [n]  AMBEPIS QTL population both 8wks N=181
Bailey1 20705 open field test (none) average velocity   [cm/sec]  AVGVELO QTL population both 8wks N=181
Bailey1 20706 open field test (none) percent resting   [%]  PCTREST QTL population both 8wks N=181
Bailey1 20707 open field test (none) activity factor  ACTFACT QTL population both 8wks N=181
Bailey1 20708 open field test (none) anxiety factor  ANXFACT QTL population both 8wks N=181

Associated genomic features
MGI-curated genes / genomic features that have been associated with this data set:
Lacanx1   Lacanx2   Lacanx3   Lacanx4  


Project / data set:   Bailey1     a.k.a. Bailey_2008
Excel file:   Data_Description_B6xC58J_Bailey2008.xlsx
CSV file:   Bailey2008_B6xC58J_B37_Data.csv
Readme / text file:   readme_Bailey2008.txt
QC plots, figures, etc.:   QCReport_Bailey2008.pdf