Project measure / variable:   GMC20   RF_21

ID, description, units MPD:56919   RF_21   rheumatoid factor (plasma RF)    at age 20-21wks  
Data set, strains GMC20   inbred w/CC8   8 strains     sex: both     age: 20-21wks
Procedure autoantibody quantification
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  STRAIN COMPARISON PLOT
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GMC20 - rheumatoid factor (plasma RF) at age 20-21wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means0.491   None 0.504   None
Median of the strain means0.471   None 0.454   None
SD of the strain means± 0.101 ± 0.179
Coefficient of variation (CV)0.206 0.356
Min–max range of strain means0.374   –   0.673   None 0.352   –   0.919   None
Mean sample size per strain8.9   mice 10.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.0035 0.0035 0.2231 0.6374
strain 7 2.1877 0.3125 19.7833 < 0.0001
sex:strain 7 0.5038 0.072 4.5561 0.0001
Residuals 141 2.2275 0.0158


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.442 0.117   10 0.0369 0.264 0.315, 0.658 -0.48
129S1/SvImJ m 0.417 0.0874   12 0.0252 0.21 0.307, 0.541 -0.48
A/J f 0.451 0.132   10 0.0417 0.292 0.329, 0.699 -0.4
A/J m 0.406 0.072   12 0.0208 0.177 0.281, 0.578 -0.54
C57BL/6J f 0.516 0.116   10 0.0365 0.224 0.373, 0.764 0.25
C57BL/6J m 0.491 0.104   12 0.03 0.212 0.341, 0.682 -0.07
CAST/EiJ f 0.39 0.0619   8 0.0219 0.159 0.288, 0.458 -1.0
CAST/EiJ m 0.404 0.114   9 0.038 0.282 0.283, 0.662 -0.56
NOD/ShiLtJ f 0.673 0.256   7 0.0967 0.38 0.424, 1.16 1.8
NOD/ShiLtJ m 0.549 0.138   9 0.0462 0.252 0.352, 0.722 0.25
NZO/HlLtJ f 0.591 0.121   7 0.0457 0.204 0.422, 0.778 0.99
NZO/HlLtJ m 0.919 0.265   9 0.0885 0.289 0.576, 1.31 2.32
PWK/PhJ f 0.491 0.112   9 0.0374 0.228 0.33, 0.67 0.0
PWK/PhJ m 0.491 0.0613   11 0.0185 0.125 0.37, 0.575 -0.07
WSB/EiJ f 0.374 0.0622   10 0.0197 0.166 0.293, 0.471 -1.16
WSB/EiJ m 0.352 0.0781   12 0.0225 0.222 0.268, 0.55 -0.85


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.4417 0.0397 0.5203 0.3631
129S1/SvImJ m 0.4168 0.0363 0.4885 0.345
A/J f 0.4515 0.0397 0.5301 0.3729
A/J m 0.4064 0.0363 0.4781 0.3347
C57BL/6J f 0.5156 0.0397 0.5942 0.437
C57BL/6J m 0.4913 0.0363 0.563 0.4195
CAST/EiJ f 0.3902 0.0444 0.4781 0.3024
CAST/EiJ m 0.4044 0.0419 0.4873 0.3216
NOD/ShiLtJ f 0.6726 0.0475 0.7665 0.5787
NOD/ShiLtJ m 0.5492 0.0419 0.632 0.4664
NZO/HlLtJ f 0.5909 0.0475 0.6848 0.4969
NZO/HlLtJ m 0.9191 0.0419 1.0019 0.8362
PWK/PhJ f 0.4906 0.0419 0.5734 0.4077
PWK/PhJ m 0.4912 0.0379 0.5661 0.4162
WSB/EiJ f 0.3736 0.0397 0.4522 0.295
WSB/EiJ m 0.3517 0.0363 0.4234 0.2799


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.4292 0.0269 0.4824 0.376
A/J both 0.429 0.0269 0.4822 0.3758
C57BL/6J both 0.5034 0.0269 0.5566 0.4502
CAST/EiJ both 0.3973 0.0305 0.4577 0.337
NOD/ShiLtJ both 0.6109 0.0317 0.6735 0.5483
NZO/HlLtJ both 0.755 0.0317 0.8176 0.6924
PWK/PhJ both 0.4909 0.0282 0.5467 0.435
WSB/EiJ both 0.3626 0.0269 0.4158 0.3094




  GWAS USING LINEAR MIXED MODELS