Project measure / variable:   GMC09   VO2_mean

ID, description, units MPD:55831   VO2_mean   mean oxygen consumption, 21 h test, 15 min bins   [mL/h]  
Data set, strains GMC09   inbred w/CC8   8 strains     sex: both     age: 12-13wks
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  STRAIN COMPARISON PLOT
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GMC09 - mean oxygen consumption, 21 h test, 15 min bins



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means75.3   mL/h 80.8   mL/h
Median of the strain means70.3   mL/h 75.1   mL/h
SD of the strain means± 16.2 ± 17.2
Coefficient of variation (CV)0.216 0.213
Min–max range of strain means58.3   –   109   mL/h 62.9   –   116   mL/h
Mean sample size per strain17.5   mice 16.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 2176.1962 2176.1962 37.5857 < 0.0001
strain 7 63469.6616 9067.0945 156.6001 < 0.0001
sex:strain 7 1541.9221 220.2746 3.8044 0.0006
Residuals 255 14764.4119 57.8997


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 58.3 10.4   16 2.6 0.178 41.0, 76.0 -1.05
129S1/SvImJ m 62.9 9.04   16 2.26 0.144 47.0, 78.0 -1.04
A/J f 66.1 5.74   16 1.43 0.0868 56.0, 78.0 -0.57
A/J m 69.3 6.14   16 1.53 0.0886 58.0, 81.0 -0.67
C57BL/6J f 70.4 3.85   16 0.962 0.0546 65.0, 79.0 -0.3
C57BL/6J m 87.1 6.88   16 1.72 0.079 77.0, 97.0 0.37
CAST/EiJ f 65.9 5.91   19 1.36 0.0896 56.0, 75.0 -0.58
CAST/EiJ m 70.3 5.93   14 1.58 0.0843 57.0, 78.0 -0.61
NOD/ShiLtJ f 89.3 11.7   18 2.76 0.131 74.0, 115.0 0.86
NOD/ShiLtJ m 90.9 5.74   16 1.44 0.0632 79.0, 97.0 0.59
NZO/HlLtJ f 109.0 7.5   17 1.82 0.0689 88.0, 119.0 2.07
NZO/HlLtJ m 116.0 6.78   17 1.65 0.0587 102.0, 131.0 2.05
PWK/PhJ f 73.2 7.4   20 1.66 0.101 58.0, 88.0 -0.13
PWK/PhJ m 79.9 7.21   20 1.61 0.0902 68.0, 93.0 -0.05
WSB/EiJ f 70.3 10.5   18 2.47 0.149 55.0, 95.0 -0.31
WSB/EiJ m 69.6 5.7   16 1.43 0.082 60.0, 79.0 -0.65


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 58.3125 1.9023 62.0587 54.5663
129S1/SvImJ m 62.875 1.9023 66.6212 59.1288
A/J f 66.125 1.9023 69.8712 62.3788
A/J m 69.3125 1.9023 73.0587 65.5663
C57BL/6J f 70.4375 1.9023 74.1837 66.6913
C57BL/6J m 87.125 1.9023 90.8712 83.3788
CAST/EiJ f 65.9474 1.7457 69.3851 62.5096
CAST/EiJ m 70.2857 2.0336 74.2906 66.2808
NOD/ShiLtJ f 89.3333 1.7935 92.8653 85.8014
NOD/ShiLtJ m 90.9375 1.9023 94.6837 87.1913
NZO/HlLtJ f 108.9412 1.8455 112.5755 105.3068
NZO/HlLtJ m 115.5882 1.8455 119.2226 111.9539
PWK/PhJ f 73.2 1.7015 76.5507 69.8493
PWK/PhJ m 79.9 1.7015 83.2507 76.5493
WSB/EiJ f 70.2778 1.7935 73.8097 66.7458
WSB/EiJ m 69.5625 1.9023 73.3087 65.8163


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 60.5937 1.3451 63.2427 57.9448
A/J both 67.7188 1.3451 70.3677 65.0698
C57BL/6J both 78.7813 1.3451 81.4302 76.1323
CAST/EiJ both 68.1165 1.3401 70.7555 65.4775
NOD/ShiLtJ both 90.1354 1.3072 92.7098 87.5611
NZO/HlLtJ both 112.2647 1.305 114.8346 109.6948
PWK/PhJ both 76.55 1.2031 78.9193 74.1807
WSB/EiJ both 69.9201 1.3072 72.4945 67.3458




  GWAS USING LINEAR MIXED MODELS