Project measure / variable:   Haston1   fibrosis

ID, description, units MPD:48802   fibrosis   percentage of lung surface covered by fibrotic scar   [%]  
radiation study
Data set, strains Haston1   inbred   26 strains     sex: both     age: 15-36wks
Procedure histopathology
Ontology mappings

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  STRAIN COMPARISON PLOT
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Haston1 - percentage of lung surface covered by fibrotic scar



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested20 strains16 strains
Mean of the strain means3.06   % 2.56   %
Median of the strain means1.84   % 1.08   %
SD of the strain means± 3.19 ± 2.74
Coefficient of variation (CV)1.04 1.07
Min–max range of strain means0   –   9.83   % 0   –   7.93   %
Mean sample size per strain7.4   mice 5.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 49.754 49.754 4.9563 0.0279
strain 9 846.114 94.0127 9.3651 < 0.0001
sex:strain 9 124.2787 13.8087 1.3756 0.2071
Residuals 116 1164.4736 10.0386


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 5.48 4.21   10 1.33 0.769 0.307, 14.7 0.76
129S1/SvImJ m 6.21 3.41   7 1.29 0.549 2.68, 11.2 1.33
A/J f 0.228 0.455   4 0.228 2.0 -0.89
A/J m 0.322 0.585   6 0.239 1.82 -0.82
AKR/J f 0.0 0.0   9 0.0 0.0 -0.96
AKR/J m 0.0 0.0   6 0.0 0.0 -0.93
BALB/cJ f 0.5 0.837   6 0.342 1.67 -0.8
BTBR T+ Itpr3tf/J f 0.758 1.23   7 0.465 1.62 -0.72
BTBR T+ Itpr3tf/J m 0.0329 0.087   7 0.0329 2.65 -0.92
BUB/BnJ f 3.42 1.66   8 0.588 0.486 1.21, 6.34 0.11
C3H/HeJ f 0.0705 0.177   10 0.0559 2.51 -0.94
C57BL/6J f 3.84 2.94   9 0.981 0.766 0.24
C57BL/6J m 5.07 4.43   3 2.56 0.874 0.92
C57BLKS/J m 7.93 7.53   5 3.37 0.949 2.2, 20.5 1.96
C58/J f 9.83 3.04   9 1.01 0.31 4.3, 13.6 2.12
CBA/J m 0.0 0.0   5 0.0 0.0 -0.93
CE/J f 0.891 0.86   8 0.304 0.965 -0.68
DBA/2J f 1.77 1.47   10 0.463 0.827 0.0678, 4.57 -0.41
DBA/2J m 0.79 0.797   10 0.252 1.01 -0.65
FVB/NJ f 7.12 6.98   9 2.33 0.981 1.16, 23.6 1.27
FVB/NJ m 4.24 1.89   7 0.714 0.445 1.5, 6.91 0.61
I/LnJ f 1.91 1.9   9 0.635 0.996 -0.36
KK/HlJ f 7.71 4.87   4 2.44 0.632 0.461, 10.9 1.46
KK/HlJ m 4.77 6.38   6 2.6 1.34 0.81
LG/J f 0.232 0.328   10 0.104 1.41 -0.89
LP/J m 0.997 0.795   3 0.459 0.798 0.2, 1.79 -0.57
MA/MyJ f 5.55 3.57   7 1.35 0.645 2.26, 13.1 0.78
NOD/ShiLtJ f 0.0 0.0   6 0.0 0.0 -0.96
NOD/ShiLtJ m 0.117 0.207   7 0.0782 1.76 -0.89
NON/ShiLtJ f 2.83 0.617   3 0.356 0.218 2.15, 3.35 -0.07
NZB/BlNJ m 6.47 2.32   3 1.34 0.358 3.94, 8.49 1.43
NZW/LacJ f 8.35 5.66   4 2.83 0.678 2.35, 14.6 1.66
NZW/LacJ m 1.86 1.35   5 0.606 0.73 -0.26
PL/J f 0.78 1.63   5 0.731 2.1 -0.72
SJL/J m 1.16 0.327   3 0.189 0.281 0.96, 1.54 -0.51
SM/J m 0.98 0.792   5 0.354 0.808 -0.58


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 5.4761 1.0019 7.4605 3.4916
129S1/SvImJ m 6.2117 1.1975 8.5836 3.8399
A/J f 0.2275 1.5842 3.3652 -2.9102
A/J m 0.3217 1.2935 2.8836 -2.2402
AKR/J f 0.0 1.0561 2.0918 -2.0918
AKR/J m 0.0 1.2935 2.5619 -2.5619
BTBR T+ Itpr3tf/J f 0.7581 1.1975 3.13 -1.6137
BTBR T+ Itpr3tf/J m 0.0329 1.1975 2.4048 -2.339
C57BL/6J f 3.8385 1.0561 5.9303 1.7467
C57BL/6J m 5.0667 1.8293 8.6897 1.4436
DBA/2J f 1.7711 1.0019 3.7555 -0.2133
DBA/2J m 0.7904 1.0019 2.7748 -1.1941
FVB/NJ f 7.1194 1.0561 9.2112 5.0277
FVB/NJ m 4.2414 1.1975 6.6133 1.8696
KK/HlJ f 7.7119 1.5842 10.8496 4.5742
KK/HlJ m 4.7702 1.2935 7.3321 2.2083
NOD/ShiLtJ f 0.0 1.2935 2.5619 -2.5619
NOD/ShiLtJ m 0.1173 1.1975 2.4891 -2.2546
NZW/LacJ f 8.3487 1.5842 11.4864 5.2111
NZW/LacJ m 1.8562 1.4169 4.6626 -0.9502


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 5.8439 0.7807 7.3902 4.2976
A/J both 0.2746 1.0226 2.2999 -1.7508
AKR/J both 0.0 0.8349 1.6537 -1.6537
BTBR T+ Itpr3tf/J both 0.3955 0.8468 2.0727 -1.2817
C57BL/6J both 4.4526 1.0561 6.5444 2.3608
DBA/2J both 1.2807 0.7085 2.6839 -0.1225
FVB/NJ both 5.6804 0.7984 7.2617 4.0992
KK/HlJ both 6.241 1.0226 8.2664 4.2157
NOD/ShiLtJ both 0.0586 0.8814 1.8043 -1.687
NZW/LacJ both 5.1025 1.0627 7.2073 2.9977




  GWAS USING LINEAR MIXED MODELS