Project measure / variable:   Johnson4   ABR_16kHz

ID, description, units MPD:42603   ABR_16kHz   auditory brainstem response (ABR) threshold, sound pressure level   [dB]  16 kHz tone stimulus  
Data set, strains Johnson4   B6.PWD consomic w/par   28 strains     sex: both     age: 49-63wks
Procedure ABR test
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  STRAIN COMPARISON PLOT
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Johnson4 - auditory brainstem response (ABR) threshold, sound pressure level 16 kHz tone stimulus



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested28 strains28 strains
Mean of the strain means68.1   dB 59.2   dB
Median of the strain means74.2   dB 61.5   dB
SD of the strain means± 16.6 ± 16.5
Coefficient of variation (CV)0.243 0.279
Min–max range of strain means22.3   –   88.5   dB 20.0   –   90.0   dB
Mean sample size per strain8.4   mice 8.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 8473.8852 8473.8852 44.9394 < 0.0001
strain 27 117901.2042 4366.7113 23.1579 < 0.0001
sex:strain 27 8012.6111 296.7634 1.5738 0.0358
Residuals 400 75424.9639 188.5624


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6.PWD-Chr1 f 56.7 14.4   6 5.87 0.254 35.0, 75.0 -0.69
B6.PWD-Chr1 m 61.7 15.4   9 5.14 0.25 35.0, 90.0 0.15
B6.PWD-Chr10.1 f 50.5 19.8   10 6.26 0.392 10.0, 75.0 -1.07
B6.PWD-Chr10.1 m 40.0 14.6   8 5.18 0.366 25.0, 70.0 -1.16
B6.PWD-Chr10.2 f 29.4 10.7   9 3.58 0.365 15.0, 50.0 -2.34
B6.PWD-Chr10.2 m 24.4 14.2   9 4.75 0.583 15.0, 60.0 -2.11
B6.PWD-Chr10.3 f 80.6 9.82   9 3.27 0.122 70.0, 100.0 0.75
B6.PWD-Chr10.3 m 70.7 7.87   7 2.97 0.111 60.0, 80.0 0.7
B6.PWD-Chr11.1 f 76.2 7.44   8 2.63 0.0976 60.0, 85.0 0.49
B6.PWD-Chr11.1 m 70.0 13.9   8 4.91 0.198 40.0, 85.0 0.66
B6.PWD-Chr11.2 f 62.0 22.5   5 10.1 0.363 25.0, 85.0 -0.37
B6.PWD-Chr11.2 m 67.2 17.5   9 5.84 0.261 40.0, 90.0 0.49
B6.PWD-Chr11.3 f 80.0 7.07   6 2.89 0.0884 70.0, 90.0 0.72
B6.PWD-Chr11.3 m 72.5 10.6   10 3.35 0.146 55.0, 90.0 0.81
B6.PWD-Chr12 f 81.4 11.4   7 4.33 0.141 65.0, 95.0 0.8
B6.PWD-Chr12 m 67.8 12.8   9 4.26 0.188 40.0, 80.0 0.52
B6.PWD-Chr13 f 80.0 10.5   6 4.28 0.131 70.0, 100.0 0.72
B6.PWD-Chr13 m 63.1 13.1   8 4.62 0.207 35.0, 75.0 0.24
B6.PWD-Chr14 f 77.0 7.15   10 2.26 0.0928 65.0, 90.0 0.54
B6.PWD-Chr14 m 71.4 9.88   7 3.73 0.138 55.0, 85.0 0.74
B6.PWD-Chr15 f 85.6 9.5   9 3.17 0.111 65.0, 100.0 1.05
B6.PWD-Chr15 m 55.0 20.4   8 7.2 0.37 30.0, 95.0 -0.25
B6.PWD-Chr16 f 88.5 8.51   10 2.69 0.0962 80.0, 100.0 1.23
B6.PWD-Chr16 m 79.4 8.21   8 2.9 0.103 70.0, 90.0 1.23
B6.PWD-Chr17 f 62.9 15.5   7 5.86 0.247 40.0, 80.0 -0.32
B6.PWD-Chr17 m 50.0 14.1   7 5.35 0.283 25.0, 70.0 -0.56
B6.PWD-Chr18 f 46.9 17.7   8 6.26 0.378 25.0, 75.0 -1.28
B6.PWD-Chr18 m 35.0 12.6   7 4.76 0.36 25.0, 55.0 -1.47
B6.PWD-Chr19 f 74.4 21.9   8 7.76 0.295 40.0, 95.0 0.38
B6.PWD-Chr19 m 47.8 16.6   9 5.53 0.348 30.0, 75.0 -0.69
B6.PWD-Chr2 f 81.4 9.88   7 3.73 0.121 70.0, 95.0 0.8
B6.PWD-Chr2 m 85.8 14.6   6 5.97 0.17 60.0, 100.0 1.62
B6.PWD-Chr3 f 47.5 19.5   8 6.88 0.41 20.0, 80.0 -1.25
B6.PWD-Chr3 m 45.7 18.6   7 7.02 0.406 25.0, 70.0 -0.82
B6.PWD-Chr5 f 86.0 10.2   10 3.23 0.119 70.0, 100.0 1.08
B6.PWD-Chr5 m 90.0 9.26   8 3.27 0.103 75.0, 100.0 1.87
B6.PWD-Chr6 f 74.4 3.0   9 1.0 0.0404 70.0, 80.0 0.38
B6.PWD-Chr6 m 59.4 21.3   8 7.53 0.359 25.0, 80.0 0.02
B6.PWD-Chr8 f 56.0 10.7   10 3.4 0.192 40.0, 75.0 -0.73
B6.PWD-Chr8 m 44.5 18.3   10 5.8 0.412 25.0, 70.0 -0.89
B6.PWD-Chr9 f 76.0 6.15   10 1.94 0.0809 65.0, 85.0 0.47
B6.PWD-Chr9 m 61.2 21.5   8 7.6 0.351 20.0, 80.0 0.12
B6.PWD-ChrX.1 f 69.4 16.8   8 5.93 0.242 30.0, 80.0 0.08
B6.PWD-ChrX.1 m 68.1 15.1   8 5.34 0.222 45.0, 95.0 0.54
B6.PWD-ChrX.2 f 75.9 8.31   11 2.51 0.11 65.0, 95.0 0.47
B6.PWD-ChrX.2 m 63.5 12.7   10 4.02 0.2 40.0, 80.0 0.26
B6.PWD-ChrX.3 f 74.0 17.8   10 5.62 0.24 25.0, 85.0 0.35
B6.PWD-ChrX.3 m 55.0 22.5   7 8.52 0.41 25.0, 80.0 -0.25
B6.PWD-ChrY f 72.9 8.09   7 3.06 0.111 65.0, 85.0 0.29
B6.PWD-ChrY m 61.4 14.9   7 5.64 0.243 35.0, 70.0 0.14
B6.PWD-mt f 73.8 5.18   8 1.83 0.0702 70.0, 85.0 0.34
B6.PWD-mt m 68.1 5.94   8 2.1 0.0872 60.0, 75.0 0.54
C57BL/6J f 66.2 18.9   8 6.66 0.285 30.0, 95.0 -0.12
C57BL/6J m 57.5 5.0   4 2.5 0.087 50.0, 60.0 -0.1
PWD/PhJ f 22.3 2.61   11 0.787 0.117 20.0, 25.0 -2.77
PWD/PhJ m 20.0 4.08   7 1.54 0.204 15.0, 25.0 -2.37


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6.PWD-Chr1 f 56.6667 5.606 67.6875 45.6458
B6.PWD-Chr1 m 61.6667 4.5773 70.6652 52.6682
B6.PWD-Chr10.1 f 50.5 4.3424 59.0367 41.9633
B6.PWD-Chr10.1 m 40.0 4.8549 49.5444 30.4556
B6.PWD-Chr10.2 f 29.4444 4.5773 38.443 20.4459
B6.PWD-Chr10.2 m 24.4444 4.5773 33.443 15.4459
B6.PWD-Chr10.3 f 80.5556 4.5773 89.5541 71.557
B6.PWD-Chr10.3 m 70.7143 5.1901 80.9176 60.5109
B6.PWD-Chr11.1 f 76.25 4.8549 85.7944 66.7056
B6.PWD-Chr11.1 m 70.0 4.8549 79.5444 60.4556
B6.PWD-Chr11.2 f 62.0 6.141 74.0728 49.9272
B6.PWD-Chr11.2 m 67.2222 4.5773 76.2207 58.2237
B6.PWD-Chr11.3 f 80.0 5.606 91.0209 68.9791
B6.PWD-Chr11.3 m 72.5 4.3424 81.0367 63.9633
B6.PWD-Chr12 f 81.4286 5.1901 91.6319 71.2252
B6.PWD-Chr12 m 67.7778 4.5773 76.7763 58.7793
B6.PWD-Chr13 f 80.0 5.606 91.0209 68.9791
B6.PWD-Chr13 m 63.125 4.8549 72.6694 53.5806
B6.PWD-Chr14 f 77.0 4.3424 85.5367 68.4633
B6.PWD-Chr14 m 71.4286 5.1901 81.6319 61.2252
B6.PWD-Chr15 f 85.5556 4.5773 94.5541 76.557
B6.PWD-Chr15 m 55.0 4.8549 64.5444 45.4556
B6.PWD-Chr16 f 88.5 4.3424 97.0367 79.9633
B6.PWD-Chr16 m 79.375 4.8549 88.9194 69.8306
B6.PWD-Chr17 f 62.8571 5.1901 73.0605 52.6538
B6.PWD-Chr17 m 50.0 5.1901 60.2033 39.7967
B6.PWD-Chr18 f 46.875 4.8549 56.4194 37.3306
B6.PWD-Chr18 m 35.0 5.1901 45.2033 24.7967
B6.PWD-Chr19 f 74.375 4.8549 83.9194 64.8306
B6.PWD-Chr19 m 47.7778 4.5773 56.7763 38.7793
B6.PWD-Chr2 f 81.4286 5.1901 91.6319 71.2252
B6.PWD-Chr2 m 85.8333 5.606 96.8542 74.8125
B6.PWD-Chr3 f 47.5 4.8549 57.0444 37.9556
B6.PWD-Chr3 m 45.7143 5.1901 55.9176 35.5109
B6.PWD-Chr5 f 86.0 4.3424 94.5367 77.4633
B6.PWD-Chr5 m 90.0 4.8549 99.5444 80.4556
B6.PWD-Chr6 f 74.4444 4.5773 83.443 65.4459
B6.PWD-Chr6 m 59.375 4.8549 68.9194 49.8306
B6.PWD-Chr8 f 56.0 4.3424 64.5367 47.4633
B6.PWD-Chr8 m 44.5 4.3424 53.0367 35.9633
B6.PWD-Chr9 f 76.0 4.3424 84.5367 67.4633
B6.PWD-Chr9 m 61.25 4.8549 70.7944 51.7056
B6.PWD-ChrX.1 f 69.375 4.8549 78.9194 59.8306
B6.PWD-ChrX.1 m 68.125 4.8549 77.6694 58.5806
B6.PWD-ChrX.2 f 75.9091 4.1403 84.0485 67.7696
B6.PWD-ChrX.2 m 63.5 4.3424 72.0367 54.9633
B6.PWD-ChrX.3 f 74.0 4.3424 82.5367 65.4633
B6.PWD-ChrX.3 m 55.0 5.1901 65.2033 44.7967
B6.PWD-ChrY f 72.8571 5.1901 83.0605 62.6538
B6.PWD-ChrY m 61.4286 5.1901 71.6319 51.2252
B6.PWD-mt f 73.75 4.8549 83.2944 64.2056
B6.PWD-mt m 68.125 4.8549 77.6694 58.5806
C57BL/6J f 66.25 4.8549 75.7944 56.7056
C57BL/6J m 57.5 6.8659 70.9978 44.0022
PWD/PhJ f 22.2727 4.1403 30.4122 14.1333
PWD/PhJ m 20.0 5.1901 30.2033 9.7967


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6.PWD-Chr1 both 59.1667 3.6186 66.2806 52.0527
B6.PWD-Chr10.1 both 45.25 3.2568 51.6525 38.8475
B6.PWD-Chr10.2 both 26.9444 3.2366 33.3073 20.5815
B6.PWD-Chr10.3 both 75.6349 3.4601 82.4372 68.8327
B6.PWD-Chr11.1 both 73.125 3.433 79.8739 66.3761
B6.PWD-Chr11.2 both 64.6111 3.8296 72.1398 57.0824
B6.PWD-Chr11.3 both 76.25 3.5455 83.2202 69.2798
B6.PWD-Chr12 both 74.6032 3.4601 81.4054 67.8009
B6.PWD-Chr13 both 71.5625 3.708 78.8521 64.2729
B6.PWD-Chr14 both 74.2143 3.3836 80.8661 67.5625
B6.PWD-Chr15 both 70.2778 3.3362 76.8365 63.719
B6.PWD-Chr16 both 83.9375 3.2568 90.34 77.535
B6.PWD-Chr17 both 56.4286 3.67 63.6434 49.2137
B6.PWD-Chr18 both 40.9375 3.5534 47.9233 33.9517
B6.PWD-Chr19 both 61.0764 3.3362 67.6351 54.5177
B6.PWD-Chr2 both 83.631 3.8198 91.1404 76.1215
B6.PWD-Chr3 both 46.6071 3.5534 53.5929 39.6214
B6.PWD-Chr5 both 88.0 3.2568 94.4025 81.5975
B6.PWD-Chr6 both 66.9097 3.3362 73.4685 60.351
B6.PWD-Chr8 both 50.25 3.0705 56.2864 44.2136
B6.PWD-Chr9 both 68.625 3.2568 75.0275 62.2225
B6.PWD-ChrX.1 both 68.75 3.433 75.4989 62.0011
B6.PWD-ChrX.2 both 69.7045 2.9999 75.6021 63.8069
B6.PWD-ChrX.3 both 64.5 3.3836 71.1518 57.8482
B6.PWD-ChrY both 67.1429 3.67 74.3577 59.928
B6.PWD-mt both 70.9375 3.433 77.6864 64.1886
C57BL/6J both 61.875 4.2045 70.1407 53.6093
PWD/PhJ both 21.1364 3.3196 27.6624 14.6103




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA