Project measure / variable:   Harrill1   ALT_trt

ID, description, units MPD:39522   ALT_trt   alanine transaminase (serum ALT)   [IU/L]  isoniazid  
isoniazid study
Data set, strains Harrill1   inbred   33 strains     sex: f     age: 8-10wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Harrill1 - alanine transaminase (serum ALT) isoniazid



  MEASURE SUMMARY
Measure Summary Female
Number of strains tested33 strains
Mean of the strain means16.8   IU/L
Median of the strain means15.5   IU/L
SD of the strain means± 6.51
Coefficient of variation (CV)0.387
Min–max range of strain means7.00   –   33.5   IU/L
Mean sample size per strain3.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 31 4429.4487 142.8854 2.0069 0.0066
Residuals 82 5838.2942 71.1987


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 20.8 12.4   4 6.19 0.596 12.5, 39.1 0.61
A/J f 23.4 5.66   2   4.0 0.242 19.4, 27.4 1.01
AKR/J f 9.5 1.91   4 0.957 0.202 7.0, 11.0 -1.12
BALB/cJ f 16.0 2.31   4 1.15 0.144 14.0, 18.0 -0.13
BTBR T+ Itpr3tf/J f 15.5 5.51   4 2.75 0.355 10.0, 22.0 -0.2
BUB/BnJ f 14.4 6.33   4 3.16 0.439 9.1, 23.5 -0.37
C3H/HeJ f 17.0 6.68   4 3.34 0.393 13.0, 27.0 0.03
C57BL/6J f 16.2 4.92   4 2.46 0.303 9.0, 20.0 -0.1
C57BLKS/J f 13.0 2.31   4 1.15 0.178 11.0, 15.0 -0.59
C57BR/cdJ f 21.1 8.33   4 4.17 0.395 12.7, 32.6 0.66
C58/J f 21.9 3.96   4 1.98 0.181 17.1, 26.8 0.78
CBA/J f 11.2 3.59   4 1.8 0.319 8.0, 16.0 -0.86
CE/J f 27.9 11.0   4 5.48 0.394 22.2, 44.3 1.7
DBA/2J f 8.75 3.77   4 1.89 0.431 5.0, 12.0 -1.24
FVB/NJ f 33.5 35.0   4 17.5 1.05 14.0, 86.0 2.56
I/LnJ f 23.4 7.92   4 3.96 0.338 16.3, 30.6 1.01
KK/HlJ f 15.3 3.13   4 1.57 0.204 12.5, 19.4 -0.23
LG/J f 20.1 4.02   3 2.32 0.199 16.6, 24.5 0.5
LP/J f 12.7 5.51   3 3.18 0.435 7.0, 18.0 -0.63
MA/MyJ f 26.8 0.0707   2   0.05 0.00264 26.7, 26.8 1.53
MRL/MpJ f 14.0 2.71   4 1.35 0.193 12.0, 18.0 -0.43
NOD/ShiLtJ f 10.7 2.29   4 1.14 0.214 7.9, 13.2 -0.94
NON/ShiLtJ f 8.8 1.83   3 1.06 0.208 6.8, 10.4 -1.23
NOR/LtJ f 7.0 1.83   4 0.913 0.261 5.0, 9.0 -1.51
NZW/LacJ f 11.0 2.94   4 1.47 0.268 7.0, 14.0 -0.89
PL/J f 13.0 3.46   3 2.0 0.266 11.0, 17.0 -0.59
PWK/PhJ f 23.4 3.94   4 1.97 0.168 18.2, 27.7 1.01
RIIIS/J f 8.33 0.306   3 0.176 0.0367 8.0, 8.6 -1.3
SEA/GnJ f 16.2 0.212   2   0.15 0.0131 16.1, 16.4 -0.1
SJL/J f 17.8 3.59   4 1.8 0.202 13.0, 21.0 0.15
SM/J f 14.5 1.84   2   1.3 0.127 13.2, 15.8 -0.36
SWR/J f 14.1 0.603   3 0.348 0.0426 13.5, 14.7 -0.42
WSB/EiJ f 27.8 0.0   1   0.0 0.0 27.8, 27.8 1.69


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 20.775 4.219 29.1679 12.3821
A/J f 23.4 5.9665 35.2693 11.5307
AKR/J f 9.5 4.219 17.8929 1.1071
BALB/cJ f 16.0 4.219 24.3929 7.6071
BTBR T+ Itpr3tf/J f 15.5 4.219 23.8929 7.1071
BUB/BnJ f 14.4 4.219 22.7929 6.0071
C3H/HeJ f 17.0 4.219 25.3929 8.6071
C57BL/6J f 16.25 4.219 24.6429 7.8571
C57BLKS/J f 13.0 4.219 21.3929 4.6071
C57BR/cdJ f 21.075 4.219 29.4679 12.6821
C58/J f 21.925 4.219 30.3179 13.5321
CBA/J f 11.25 4.219 19.6429 2.8571
CE/J f 27.85 4.219 36.2429 19.4571
DBA/2J f 8.75 4.219 17.1429 0.3571
FVB/NJ f 33.5 4.219 41.8929 25.1071
I/LnJ f 23.4 4.219 31.7929 15.0071
KK/HlJ f 15.35 4.219 23.7429 6.9571
LG/J f 20.1333 4.8716 29.8246 10.4421
LP/J f 12.6667 4.8716 22.3579 2.9754
MA/MyJ f 26.75 5.9665 38.6193 14.8807
MRL/MpJ f 14.0 4.219 22.3929 5.6071
NOD/ShiLtJ f 10.675 4.219 19.0679 2.2821
NON/ShiLtJ f 8.8 4.8716 18.4912 0.0
NOR/LtJ f 7.0 4.219 15.3929 0.0
NZW/LacJ f 11.0 4.219 19.3929 2.6071
PL/J f 13.0 4.8716 22.6912 3.3088
PWK/PhJ f 23.425 4.219 31.8179 15.0321
RIIIS/J f 8.3333 4.8716 18.0246 0.0
SEA/GnJ f 16.25 5.9665 28.1193 4.3807
SJL/J f 17.75 4.219 26.1429 9.3571
SM/J f 14.5 5.9665 26.3693 2.6307
SWR/J f 14.1333 4.8716 23.8246 4.4421




  GWAS USING LINEAR MIXED MODELS