Project measure / variable:   Paigen3   microvacs

ID, description, units MPD:2830   microvacs   liver microvacuoles (score: 0-4)   [score]  
high-fat diet study
Data set, strains Paigen3   obesity mutants   7 strains     sex: both     age: 15-19wks
Procedure histopathology
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen3 - liver microvacuoles (score: 0-4)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means3.05   score 3.13   score
Median of the strain means3.00   score 3.00   score
SD of the strain means± 0.826 ± 0.659
Coefficient of variation (CV)0.271 0.211
Min–max range of strain means2.00   –   4.00   score 2.33   –   4.00   score
Mean sample size per strain3.0   mice 3.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.0846 0.0846 0.7182 0.4037
strain 6 18.1833 3.0305 25.7227 < 0.0001
sex:strain 6 1.9433 0.3239 2.7491 0.0307
Residuals 29 3.4167 0.1178


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6(AU)-Tubtub/J f 3.33 0.577   3 0.333 0.173 3.0, 4.0 0.34
B6(AU)-Tubtub/J m 3.25 0.5   4 0.25 0.154 3.0, 4.0 0.18
B6.Cg-Ay/J f 3.0 0.0   3 0.0 0.0 3.0, 3.0 -0.06
B6.Cg-Ay/J m 2.67 0.577   3 0.333 0.217 2.0, 3.0 -0.7
B6.Cg-Lepob/J f 4.0 0.0   3 0.0 0.0 4.0, 4.0 1.15
B6.Cg-Lepob/J m 4.0 0.0   3 0.0 0.0 4.0, 4.0 1.32
BKS.Cg-Dock7m +/+ Leprdb/J f 4.0 0.0   3 0.0 0.0 4.0, 4.0 1.15
BKS.Cg-Dock7m +/+ Leprdb/J m 4.0 0.0   3 0.0 0.0 4.0, 4.0 1.32
BKSChpLt.HRS-Cpefat/J f 2.0 0.0   3 0.0 0.0 2.0, 2.0 -1.27
BKSChpLt.HRS-Cpefat/J m 3.0 0.0   3 0.0 0.0 3.0, 3.0 -0.2
C57BL/6J f 3.0 0.0   3 0.0 0.0 3.0, 3.0 -0.06
C57BL/6J m 2.67 0.577   3 0.333 0.217 2.0, 3.0 -0.7
C57BLKS/J f 2.0 0.0   3 0.0 0.0 2.0, 2.0 -1.27
C57BLKS/J m 2.33 0.577   3 0.333 0.247 2.0, 3.0 -1.22


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J f 3.3333 0.1982 3.7386 2.928
B6(AU)-Tubtub/J m 3.25 0.1716 3.601 2.899
B6.Cg-Ay/J f 3.0 0.1982 3.4053 2.5947
B6.Cg-Ay/J m 2.6667 0.1982 3.072 2.2614
B6.Cg-Lepob/J f 4.0 0.1982 4.4053 3.5947
B6.Cg-Lepob/J m 4.0 0.1982 4.4053 3.5947
BKS.Cg-Dock7m +/+ Leprdb/J f 4.0 0.1982 4.4053 3.5947
BKS.Cg-Dock7m +/+ Leprdb/J m 4.0 0.1982 4.4053 3.5947
BKSChpLt.HRS-Cpefat/J f 2.0 0.1982 2.4053 1.5947
BKSChpLt.HRS-Cpefat/J m 3.0 0.1982 3.4053 2.5947
C57BL/6J f 3.0 0.1982 3.4053 2.5947
C57BL/6J m 2.6667 0.1982 3.072 2.2614
C57BLKS/J f 2.0 0.1982 2.4053 1.5947
C57BLKS/J m 2.3333 0.1982 2.7386 1.928


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J both 3.2917 0.1311 3.5598 3.0236
B6.Cg-Ay/J both 2.8333 0.1401 3.1199 2.5467
B6.Cg-Lepob/J both 4.0 0.1401 4.2866 3.7134
BKS.Cg-Dock7m +/+ Leprdb/J both 4.0 0.1401 4.2866 3.7134
BKSChpLt.HRS-Cpefat/J both 2.5 0.1401 2.7866 2.2134
C57BL/6J both 2.8333 0.1401 3.1199 2.5467
C57BLKS/J both 2.1667 0.1401 2.4533 1.8801




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA