Project measure / variable:   Jaxpheno3   CHOL16

ID, description, units MPD:22831   CHOL16   cholesterol (plasma CHOL)   [mg/dL]  at age 16wks  
Data set, strains Jaxpheno3   inbred   8 strains     sex: both     age: 16wks
Procedure lipid profile
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  STRAIN COMPARISON PLOT
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Jaxpheno3 - cholesterol (plasma CHOL) at age 16wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested8 strains8 strains
Mean of the strain means83.9   mg/dL 109   mg/dL
Median of the strain means75.6   mg/dL 108   mg/dL
SD of the strain means± 19.9 ± 11.9
Coefficient of variation (CV)0.237 0.109
Min–max range of strain means68.9   –   126   mg/dL 93.3   –   131   mg/dL
Mean sample size per strain16.2   mice 16.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 23477.948 23477.948 28.3236 < 0.0001
strain 7 58126.1946 8303.7421 10.0176 < 0.0001
sex:strain 7 25052.0534 3578.8648 4.3175 0.0002
Residuals 245 203084.9381 828.9181


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6D2F1/J f 84.2 12.0   10 3.81 0.143 69.0, 108.0 0.02
B6D2F1/J m 116.0 4.29   10 1.36 0.0369 112.0, 127.0 0.62
BALB/cByJ f 68.9 7.09   20 1.58 0.103 57.0, 83.0 -0.75
BALB/cByJ m 113.0 10.9   20 2.44 0.0962 89.0, 128.0 0.37
C3H/HeJ f 100.0 11.9   10 3.77 0.119 82.0, 120.0 0.81
C3H/HeJ m 131.0 14.1   10 4.45 0.108 101.0, 147.0 1.89
C57BL/6J f 69.8 6.05   30 1.11 0.0867 57.0, 82.0 -0.71
C57BL/6J m 93.3 10.2   30 1.87 0.11 79.0, 121.0 -1.29
CBA/J f 78.1 5.47   10 1.73 0.07 70.0, 87.0 -0.29
CBA/J m 99.3 17.1   20 3.83 0.173 77.0, 127.0 -0.79
DBA/2J f 70.9 7.56   10 2.39 0.107 62.0, 87.0 -0.65
DBA/2J m 107.0 3.46   10 1.1 0.0324 102.0, 112.0 -0.14
NOD.CB17-Prkdcscid/J f 73.1 4.56   10 1.44 0.0623 64.0, 82.0 -0.54
NOD.CB17-Prkdcscid/J m 99.4 9.44   10 2.99 0.095 78.0, 114.0 -0.78
NOD/ShiLtJ f 126.0 79.1   30 14.4 0.627 57.0, 361.0 2.12
NOD/ShiLtJ m 110.0 11.3   21 2.46 0.102 87.0, 132.0 0.12


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6D2F1/J f 84.2 9.1045 102.1331 66.2669
B6D2F1/J m 116.2 9.1045 134.1331 98.2669
BALB/cByJ f 68.9 6.4378 81.5806 56.2194
BALB/cByJ m 113.3 6.4378 125.9806 100.6194
C3H/HeJ f 100.1 9.1045 118.0331 82.1669
C3H/HeJ m 130.8 9.1045 148.7331 112.8669
C57BL/6J f 69.8 5.2565 80.1537 59.4463
C57BL/6J m 93.2667 5.2565 103.6203 82.913
CBA/J f 78.1 9.1045 96.0331 60.1669
CBA/J m 99.3 6.4378 111.9806 86.6194
DBA/2J f 70.9 9.1045 88.8331 52.9669
DBA/2J m 107.0 9.1045 124.9331 89.0669
NOD.CB17-Prkdcscid/J f 73.1 9.1045 91.0331 55.1669
NOD.CB17-Prkdcscid/J m 99.4 9.1045 117.3331 81.4669
NOD/ShiLtJ f 126.1 5.2565 136.4537 115.7463
NOD/ShiLtJ m 109.8571 6.2827 122.2321 97.4822


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6D2F1/J both 100.2 6.4378 112.8806 87.5194
BALB/cByJ both 91.1 4.5522 100.0665 82.1335
C3H/HeJ both 115.45 6.4378 128.1306 102.7694
C57BL/6J both 81.5333 3.7169 88.8545 74.2122
CBA/J both 88.7 5.5753 99.6817 77.7183
DBA/2J both 88.95 6.4378 101.6306 76.2694
NOD.CB17-Prkdcscid/J both 86.25 6.4378 98.9306 73.5694
NOD/ShiLtJ both 117.9786 4.0958 126.0461 109.9111




  GWAS USING LINEAR MIXED MODELS