Project measure / variable:   Jaxpheno3   CHOL8

ID, description, units MPD:22830   CHOL8   cholesterol (plasma CHOL)   [mg/dL]  at age 8wks  
Data set, strains Jaxpheno3   inbred   11 strains     sex: both     age: 8wks
Procedure lipid profile
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  STRAIN COMPARISON PLOT
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Jaxpheno3 - cholesterol (plasma CHOL) at age 8wks



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested11 strains11 strains
Mean of the strain means140   mg/dL 163   mg/dL
Median of the strain means80.0   mg/dL 110   mg/dL
SD of the strain means± 180 ± 165
Coefficient of variation (CV)1.28 1.01
Min–max range of strain means71.8   –   680   mg/dL 78.0   –   655   mg/dL
Mean sample size per strain15.8   mice 17.1   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 29125.5479 29125.5479 107.6884 < 0.0001
strain 10 6286991.074 628699.1074 2324.5429 < 0.0001
sex:strain 10 25724.3687 2572.4369 9.5113 < 0.0001
Residuals 378 102234.4069 270.4614


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6.129P2-Apoetm1Unc/J f 680.0 71.2   10 22.5 0.105 577.0, 782.0 3.0
B6.129P2-Apoetm1Unc/J m 655.0 56.7   10 17.9 0.0865 566.0, 744.0 2.99
B6D2F1/J f 81.0 6.41   10 2.03 0.0792 70.0, 91.0 -0.33
B6D2F1/J m 128.0 8.07   10 2.55 0.0632 114.0, 139.0 -0.21
BALB/cByJ f 76.0 6.86   20 1.53 0.0903 60.0, 86.0 -0.36
BALB/cByJ m 102.0 8.19   20 1.83 0.0801 84.0, 115.0 -0.37
BALB/cJ f 80.0 7.93   20 1.77 0.0991 68.0, 95.0 -0.33
BALB/cJ m 78.0 7.23   22 1.54 0.0926 63.0, 92.0 -0.51
C3H/HeJ f 111.0 3.8   10 1.2 0.0342 106.0, 117.0 -0.16
C3H/HeJ m 131.0 9.37   10 2.96 0.0718 119.0, 151.0 -0.19
C57BL/6J f 79.2 8.83   30 1.61 0.112 64.0, 99.0 -0.34
C57BL/6J m 100.0 11.9   54 1.62 0.119 66.0, 132.0 -0.38
CBA/J f 78.0 7.99   21 1.74 0.102 63.0, 92.0 -0.34
CBA/J m 113.0 7.88   30 1.44 0.0697 92.0, 126.0 -0.3
DBA/2J f 83.3 10.6   21 2.3 0.127 68.0, 107.0 -0.32
DBA/2J m 110.0 9.51   20 2.13 0.0866 94.0, 136.0 -0.32
FVB/NJ f 120.0 9.64   10 3.05 0.0804 104.0, 133.0 -0.11
FVB/NJ m 163.0 10.8   12 3.13 0.0665 146.0, 179.0 0.0
NOD.CB17-Prkdcscid/J f 71.8 5.55   10 1.76 0.0774 61.0, 79.0 -0.38
NOD.CB17-Prkdcscid/J m 101.0 4.48   10 1.42 0.0443 94.0, 109.0 -0.37
NOD/ShiLtJ f 79.3 6.78   20 1.52 0.0855 68.0, 98.0 -0.34
NOD/ShiLtJ m 108.0 7.54   20 1.69 0.0699 93.0, 124.0 -0.33


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6.129P2-Apoetm1Unc/J f 679.8 5.2006 690.0257 669.5743
B6.129P2-Apoetm1Unc/J m 654.9 5.2006 665.1257 644.6743
B6D2F1/J f 81.0 5.2006 91.2257 70.7743
B6D2F1/J m 127.7 5.2006 137.9257 117.4743
BALB/cByJ f 76.0 3.6774 83.2307 68.7693
BALB/cByJ m 102.2 3.6774 109.4307 94.9693
BALB/cJ f 80.05 3.6774 87.2807 72.8193
BALB/cJ m 78.0455 3.5062 84.9396 71.1513
C3H/HeJ f 111.3 5.2006 121.5257 101.0743
C3H/HeJ m 130.6 5.2006 140.8257 120.3743
C57BL/6J f 79.1667 3.0026 85.0705 73.2628
C57BL/6J m 100.1667 2.238 104.5671 95.7662
CBA/J f 78.0476 3.5887 85.104 70.9912
CBA/J m 113.2 3.0026 119.1038 107.2962
DBA/2J f 83.3333 3.5887 90.3897 76.2769
DBA/2J m 109.9 3.6774 117.1307 102.6693
FVB/NJ f 119.9 5.2006 130.1257 109.6743
FVB/NJ m 162.9167 4.7475 172.2514 153.5819
NOD.CB17-Prkdcscid/J f 71.8 5.2006 82.0257 61.5743
NOD.CB17-Prkdcscid/J m 101.1 5.2006 111.3257 90.8743
NOD/ShiLtJ f 79.3 3.6774 86.5307 72.0693
NOD/ShiLtJ m 107.9 3.6774 115.1307 100.6693


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6.129P2-Apoetm1Unc/J both 667.35 3.6774 674.5807 660.1193
B6D2F1/J both 104.35 3.6774 111.5807 97.1193
BALB/cByJ both 89.1 2.6003 94.2129 83.9871
BALB/cJ both 79.0477 2.5405 84.043 74.0524
C3H/HeJ both 120.95 3.6774 128.1807 113.7193
C57BL/6J both 89.6667 1.8724 93.3483 85.985
CBA/J both 95.6238 2.3396 100.224 91.0236
DBA/2J both 96.6167 2.5692 101.6683 91.565
FVB/NJ both 141.4083 3.5208 148.3312 134.4855
NOD.CB17-Prkdcscid/J both 86.45 3.6774 93.6807 79.2193
NOD/ShiLtJ both 93.6 2.6003 98.7129 88.4871




  GWAS USING LINEAR MIXED MODELS