Project measure / variable:   Bennett4   TMAO_base_HFHS

ID, description, units MPD:114766   TMAO_base_HFHS   plasma trimethylamine N-oxide (TMAO) amount, baseline   [µM]  HFHS group  
various diets 2 study
Data set, strains Bennett4   CC   22 strains     sex: f     age: 8-11wks
Procedure biomarker quantification
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  STRAIN COMPARISON PLOT
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Bennett4 - plasma trimethylamine N-oxide (TMAO) amount, baseline HFHS group



  MEASURE SUMMARY
Measure Summary Female
Number of strains tested22 strains
Mean of the strain means5.7184   µM
Median of the strain means5.29   µM
SD of the strain means± 3.7296
Coefficient of variation (CV)0.6522
Min–max range of strain means0.94   –   13.92   µM
Mean sample size per strain4.6   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
strain 21 1272.1231 60.5773 3.5417 < 0.0001
Residuals 79 1351.2155 17.104


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
CC001/Unc f 2.82 0.85264   5 0.38131 0.3024 1.9, 4.2 -0.78
CC002/Unc f 5.3 2.4321   5 1.0877 0.4589 3.1, 9.0 -0.11
CC004/TauUnc f 3.08 1.8075   5 0.80833 0.5868 1.0, 5.9 -0.71
CC006/TauUnc f 6.125 1.8945   4 0.94725 0.3093 3.5, 8.0 0.11
CC008/GeniUnc f 1.65 0.68069   4 0.34034 0.4125 0.7, 2.3 -1.09
CC011/Unc f 2.84 0.73689   5 0.32955 0.2595 2.0, 3.8 -0.77
CC012/GeniUnc f 8.54 8.1362   5 3.6386 0.9527 2.7, 21.8 0.76
CC019/TauUnc f 10.02 6.1581   5 2.754 0.6146 3.0, 16.8 1.15
CC024/GeniUnc f 2.5 0.14142   2   0.1 0.0566 2.4, 2.6 -0.86
CC027/GeniUnc f 5.28 1.9677   5 0.88 0.3727 2.6, 7.6 -0.12
CC028/GeniUnc f 2.1 0.93095   4 0.46547 0.4433 1.2, 3.4 -0.97
CC030/GeniUnc f 6.26 2.0354   5 0.91027 0.3251 3.5, 8.1 0.15
CC032/GeniUnc f 11.18 7.6162   5 3.4061 0.6812 3.7, 23.1 1.46
CC035/Unc f 13.92 7.6585   5 3.425 0.5502 7.0, 27.0 2.2
CC036/Unc f 7.4 6.0071   5 2.6864 0.8118 2.8, 17.7 0.45
CC037/TauUnc f 5.72 1.9344   5 0.8651 0.3382 3.4, 7.7 0.0
CC040/TauUnc f 4.48 2.4407   5 1.0915 0.5448 1.6, 7.5 -0.33
CC041/TauUnc f 2.48 1.6888   5 0.75525 0.681 1.2, 5.4 -0.87
CC045/GeniUnc f 5.35 2.1455   4 1.0728 0.401 2.9, 7.2 -0.1
CC059/TauUnc f 4.12 2.0777   5 0.92919 0.5043 2.0, 6.5 -0.43
CC063/Unc f 13.7 8.7573   3 5.056 0.6392 7.4, 23.7 2.14
CC071/TauUnc f 0.94 0.33615   5 0.15033 0.3576 0.5, 1.4 -1.28


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
CC001/Unc f 2.82 1.8495401413 6.501417563 -0.861417563
CC002/Unc f 5.3 1.8495401413 8.981417563 1.618582437
CC004/TauUnc f 3.08 1.8495401413 6.761417563 -0.601417563
CC006/TauUnc f 6.125 2.0678487415 10.2409499622 2.0090500378
CC008/GeniUnc f 1.65 2.0678487415 5.7659499622 -2.4659499622
CC011/Unc f 2.84 1.8495401413 6.521417563 -0.841417563
CC012/GeniUnc f 8.54 1.8495401413 12.221417563 4.858582437
CC019/TauUnc f 10.02 1.8495401413 13.701417563 6.338582437
CC024/GeniUnc f 2.5 2.9243797352 8.3208322587 -3.3208322587
CC027/GeniUnc f 5.28 1.8495401413 8.961417563 1.598582437
CC028/GeniUnc f 2.1 2.0678487415 6.2159499622 -2.0159499622
CC030/GeniUnc f 6.26 1.8495401413 9.941417563 2.578582437
CC032/GeniUnc f 11.18 1.8495401413 14.861417563 7.498582437
CC035/Unc f 13.92 1.8495401413 17.601417563 10.238582437
CC036/Unc f 7.4 1.8495401413 11.081417563 3.718582437
CC037/TauUnc f 5.72 1.8495401413 9.401417563 2.038582437
CC040/TauUnc f 4.48 1.8495401413 8.161417563 0.798582437
CC041/TauUnc f 2.48 1.8495401413 6.161417563 -1.201417563
CC045/GeniUnc f 5.35 2.0678487415 9.4659499622 1.2340500378
CC059/TauUnc f 4.12 1.8495401413 7.801417563 0.438582437
CC063/Unc f 13.7 2.3877460551 18.4526896373 8.9473103627
CC071/TauUnc f 0.94 1.8495401413 4.621417563 -2.741417563




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA