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Data set / project: Payseur1   (2015)

Project Gough Island x WSB intercross to investigate body weight

Payseur1     MPD:539     2015     QTLA: Payseur_2015

AfilliationChurchill Group QTL Archive
Investigators Bret A Payseur     University of Wisconsin   Madison, WI
Contact Bret A Payseur
payseur@wisc.edu
Other participants Gray MM, Parmenter MD, Hogan CA, Ford I, Cuthbert RJ, Ryan PG, Broman KW
Introductory
description

The mice on the remote Gough Island evolved the largest body size among wild house mice from around the world. Through comparisons with a smaller-bodied wild-derived strain from the same subspecies (WSB/EiJ), we demonstrated that Gough Island mice achieve their exceptional body weight primarily by growing faster during the 6 weeks after birth. We used genetic mapping in large F2 intercrosses between Gough Island mice and WSB/EiJ to identify quantitative trait loci (QTL) responsible for the evolution of 16-week weight trajectories.

Availability
 Available download files:
Excel file with descriptions and data: • Data_Description_Payseur2015.xlsx
CSV files • Payseur2015_goughF2.csv
Large zipped data sets / archives • goughF2.zip
Readme / text files: • readme_Payseur2015.txt
Progenitors: wild Gough Island mice   WSB/EiJ         Cross type: F2 intercross
Population size: 594     618    


Studied phenotypes
wkN   raw body weight, age 1wk to age 16wks (16 phenotypes) [g] age 1-16wks  
wkN_sm   smoothed body weights, age 1wk to age 16wks (16 phenotypes) [g] age 1-16wks  
wkN_deriv   estimated 1st derivative of body weight, age 1wk to age 16wks (16 phenotypes) [g] age 1-16wks  
Ontology term mappings

Phenotyping methodologies utilized:   • body weight    


Notes and
funding
Grant: This project was supported by National Institutes of Health grant R01GM100426A (to BAP), NIH National Research Service Award 1F32GM090685 (to MMG), and a National Science Foundation graduate research fellowship (to MDP)
Changelog No updates or corrections have been posted since initial release in Jan 2016

Reference
Gray MM, Parmenter MD, Hogan CA, Ford I, Cuthbert RJ, Ryan PG, Broman KW, Payseur BA. Genetics of Rapid and Extreme Size Evolution in Island Mice. Genetics. 2015 Sep;201(1):213-28. doi: 10.1534/genetics.115.177790. Epub 2015 Jul 20.     PubMed 26199233     MGI     FullText

 




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