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Data set / project: Broman1   (2006)

Project Gut length in a mouse intercross between C3HeB/FeJ and C57BL/6J, with one F1 parent carrying the Sox10Dom mutation

Broman1     MPD:183     2006     QTLA: Broman_2006

AfilliationChurchill Group QTL Archive
Investigators Karl W Broman     University of Wisconsin   Madison, WI
Contact Karl W Broman
kbroman@biostat.wisc.edu
Other participants Sen S, Owens SE, Manichaikul A, Southard-Smith EM, Churchill GA
  A mouse intercross between C3HeBFeJ (C3) and C57BL/6J (B6), with one F1 parent carrying the Sox10Dom mutation. There are 1068 mice from reciprocal intercrosses. Over 2000 mice were generated, but only those individuals heterozygous at Sox10Dom were genotyped and included in the data set. Sox10 is on chromosome 15, and so that chromosome exhibits an unusual segregation pattern. Some mice received the mutation from their mother and some from their father. The primary phenotype is gut length (in cm). The phenotype cross indicates the cross used to generate an animal.
Availability
 Available download files:
Excel file with descriptions and data: • Data_Description_B6xC3_Broman2006.xlsx
CSV files • Broman2006_B6xC3_B37_Data.csv
Readme / text files: • readme_Broman2006.txt
QC plots, figures, etc.: • QCReport_Broman2006.pdf
Progenitors: B6.Sox10Dom   C3HeB/FeJ   C57BL/6J         Cross type: F2 reciprocal intercross
Cross direction notation: see Excel file
Population size: 505     563    


Studied phenotypes
gutlength   gut length of mouse [cm] age  
Ontology term mappings

Phenotyping methodologies utilized:   • organ dimensions    



Genomic features
MGI-curated genomic features associated with this data set.   This curation is ongoing.
(syntenic) Gutl1 MGI info
(syntenic) Sox10m2 MGI info
(syntenic) Sox10m3 MGI info
(syntenic) Sox10m4 MGI info
(syntenic) Sox10m5 MGI info


Notes and
funding
This work was supported by a Foundation for Digestive Health and Nutrition Research Scholar Award and US National Institutes of Health grants from NINDS (NS43556) and NIDDK (DK60047) to E.M.S2.
Changelog No updates or corrections have been posted since initial release in Oct 2009
Relocated to MPD from http://qtlarchive.org in Feb 2015.

Reference
Broman KW, Sen S, Owens SE, Manichaikul A, Southard-Smith EM, Churchill GA. The X chromosome in quantitative trait locus mapping. Genetics. 2006 Dec;174(4):2151-8. Epub 2006 Oct 8.     PubMed 17028340     MGI     FullText

Owens SE, Broman KW, Wiltshire T, Elmore JB, Bradley KM, Smith JR, Southard-Smith EM. Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease. Hum Mol Genet. 2005 Jun 1;14(11):1549-58. Epub 2005 Apr 20.     PubMed 15843399     MGI

 




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