||Gut length in a mouse intercross between C3HeB/FeJ and C57BL/6J, with one F1 parent carrying the Sox10Dom mutation
|Afilliation||Churchill Group QTL Archive
Karl W Broman
University of Wisconsin Madison, WI
Karl W Broman
||Sen S, Owens SE, Manichaikul A, Southard-Smith EM, Churchill GA
A mouse intercross between C3HeBFeJ (C3) and C57BL/6J (B6), with one F1 parent carrying the Sox10Dom mutation. There are 1068 mice from reciprocal intercrosses. Over 2000 mice were generated, but only those individuals heterozygous at Sox10Dom were genotyped and included in the data set. Sox10 is on chromosome 15, and so that chromosome exhibits an unusual segregation pattern. Some mice received the mutation from their mother and some from their father. The primary phenotype is gut length (in cm). The phenotype cross indicates the cross used to generate an animal.
Available download files:
Cross type: F2 reciprocal intercross
Cross direction notation: see Excel file
MGI-curated genomic features associated with
this data set.
This curation is ongoing.
This work was supported by a Foundation for Digestive Health and Nutrition Research Scholar Award and US National Institutes of Health grants from NINDS (NS43556) and NIDDK (DK60047) to E.M.S2.
No updates or corrections have been
posted since initial release
Relocated to MPD from http://qtlarchive.org in Feb 2015.
Broman KW, Sen S, Owens SE, Manichaikul A, Southard-Smith EM, Churchill GA. The X chromosome in quantitative trait locus mapping.
Genetics. 2006 Dec;174(4):2151-8. Epub 2006 Oct 8.
Owens SE, Broman KW, Wiltshire T, Elmore JB, Bradley KM, Smith JR, Southard-Smith EM. Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease.
Hum Mol Genet. 2005 Jun 1;14(11):1549-58. Epub 2005 Apr 20.