Mahler1: Subphenotypes of colitis susceptibility in IL-10-deficient mice generated from backcrosses involving C3H/HeJBir and C57BL/6J (2002)

Mahler M, Most C, Schmidtke S, Sundberg JP, Li R, Hedrich HJ, Churchill GA. Genetics of colitis susceptibility in IL-10-deficient mice: backcross versus F2 results contrasted by principal component analysis. Genomics. 2002 Sep;80(3):274-82.   PubMed 12213197  


       
Mahler1 downloads
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Investigators M Mahler
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
Participants Most C, Schmidtke S, Sundberg JP, Li R, Hedrich HJ
ContactGary A Churchill     gary.churchill@jax.org
Affiliated CenterQTL Archive
AcknowledgementsFunding provided by NIH DK44240, CA34196; and the Deutsche Forschungsgemeinschaft
Project type QTL Archive data set
MPD identifiersMahler1     MPD:121
Data changelog No updates/corrections.       Initial release date: 01/2008.
Backcrosses involving C3H/HeJBir and C57BL/6J inbred mouse strains homozygous for the disrupted Il10 gene were generated to identify QTLs involved in colitis susceptibility. Spleens were assessed in backcross progeny and the cecum and colon were scored for lesions based on severity, ulceration, hyperplasia, and percentage of area involved. For detailed protocols see Mahler et al 2002.


QTL data set parameters:
Cross 1: (C3H x B6) x B6 backcross       Mahler1
Progenitor strains B6.Il10-/-     C3H.Il10-/-    
Cross direction notation(C3H x B6) x B6
Cross typeBackcross
Population size 100 ♀     103 ♂
NotesN2 progeny
Age6wks

Progenitor strains B6.Il10-/-     C3H.Il10-/-    
Cross typeNone
Population size None ♀     None ♂
Age6wks


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Associated genomic features
MGI-curated QTL / genomic features that have been associated with this data set:
Cdcs10   Cdcs7   Cdcs8   Cdcs9  


Cross 1: (C3H x B6) x B6 backcross     Mahler1     a.k.a. Mahler_2002a
Excel file:   Data_Description_C3HxB6_Mahler2002a.xlsx
CSV file:   Mahler2002a_B6BC_B37_Data.csv
Readme / text file:   readme_Mahler2002a.txt
QC plots, figures, etc.:   QCReport_Mahler2002a.pdf

Project / data set:   Mahler1b     a.k.a. None

QTL file list not available on this MPD instance.