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Data set: Sandell1   (2012)

  Ear wound healing and articular cartilage regeneration in 6 inbred and 9 LGXSM recombinant inbred strains of mice
  Bilateral ear punctures were made in 6-wk old mice and healing outcomes were measured after 30 d. At 8 wks of age, acute full-thickness articular cartilage injuries were introduced in the trochlear groove. Mouse knee joints were sectioned at indicated times post-injury and stained to evaluate regeneration. Time course analysis showed no significant regeneration until 16 wks post-wounding.
 

Study design: baseline survey   1 cohort.
15 strains tested     female male     Test age: 6-7wks
Sample sizes are 5.6 on average. ... Caution, some N ≤ 2 are present  [details]

  Investigators: Sandell LJ     [More info... papers, citing, funding]

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Sandell1
phenotype
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wound healing         health assessment  
Sandell1
ear cartilage wound healing 30d post-injury   [mm] 15 strains   age 10wks
  LGXSM
 
wound healing         histopathology  
Sandell1
articular cartilage wound healing post-injury [score]        
• 12wks  • 16wks      comparison  
15 strains   age 20wks
  LGXSM




One update or correction was posted since initial release in May 2014
 
Rai MF, Hashimoto S, Johnson EE, Janiszak KL, Fitzgerald J, Heber-Katz E, Cheverud JM, Sandell LJ. Heritability of articular cartilage regeneration and its association with ear wound healing in mice. Arthritis Rheum. 2012 Jul;64(7):2300-10. doi: 10.1002/art.34396.     PubMed 22275233     MGI     FullText




 




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