|Project data set: Nelson1 (2010)|
Effects of dietary restriction on body composition and lifespan: life extension and life shortening in 44 ILSXISS recombinant inbred strains of mice
Two cohorts: 1) control mice fed ad libitum, and 2) test mice subjected to 40% dietary
restriction (60% of ad libitum diet). Dietary restriction started at 2-5 mo of age.
All mice from both cohorts were weighed and assessed for body composition at 15-17 mo of age.
Lifespan data was collected.
control vs. intervention;
44 strains tested
Nelson JF, Johnson TE
View phenotyping protocol and methods
Number of mice tested per strain, for each measurement
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There has been
one update or correction
to the data set since MPD release
Liao CY, Rikke BA, Johnson TE, Diaz V, Nelson JF. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening.
Aging Cell. 2010 Feb;9(1):92-5. Epub 2009 Oct 30.
Liao CY, Rikke BA, Johnson TE, Gelfond JA, Diaz V, Nelson JF. Fat maintenance is a predictor of the murine lifespan response to dietary restriction.
Aging Cell. 2011 Aug;10(4):629-39. doi: 10.1111/j.1474-9726.2011.00702.x. Epub 2011 Apr 25.
Strain and animal info
Strain names for mice tested prior to importation to The Jackson Laboratory have been
updated using current strain nomenclature and assigned JAX vendor codes (if available) in order to facilitate comparisons across projects.
Some measurements were derived by MPD staff,
based on supplied data. [View list]
See also the MPD download center for more general data download options.