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Project data set: Dietrich1   (1998)

Project Bacillus anthracis lethal toxin susceptibility in females of 50 strains of mice

Study design: baseline survey; 1 cohort.
50 strains tested     female only     Test age: 6-8wks*

Investigators Dietrich WF   [Details, papers]

Protocol View phenotyping protocol and methods

Dietrich1
measurements



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          Ontologies


immune system — response to bacterial infection — anthrax         in vitro assay  
Dietrich1
macrophage susceptibility to Bacillus anthracis
lethal toxin (0=susceptible; 1=resistant)
  [designation]  
Bacillus anthracis lethal toxin  
50 strains   age 6-8wks*
  Inbred



Number of mice tested per strain, for each measurement

  
Changelog There have been 3 updates or corrections to the data set since MPD release in Dec 2001  
Reference
Boyden ED, Dietrich WF. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet. 2006 Feb;38(2):240-4. Epub 2006 Jan 22.     PubMed 16429160     MGI


Roberts JE, Watters JW, Ballard JD, Dietrich WF. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. Mol Microbiol. 1998 Jul;29(2):581-91.     PubMed 9720874     MGI


Watters JW, Dewar K, Lehoczky J, Boyartchuk V, Dietrich WF. Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor. Curr Biol. 2001 Oct 2;11(19):1503-11.     PubMed 11591317     MGI


Watters JW, Dietrich WF. Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11. Genomics. 2001 Apr 15;73(2):223-31.     PubMed 11318612     MGI

Mice
Strain and animal info
Note
Resistant is defined as cells that show greater than 90% viability when incubated 4 hr with lethal factor (LF; 10 micrograms/milliliter) and protective antigen (PA; 1 microgram/milliliter).

Susceptible is defined as cells that show less than 10% viability under the same conditions.


Dietrich1
downloads


Individual animal dataNot accessioned
Strain means (.csv) Strain means with SD, N, other summary statistics. One row per strain / sex / measurement.
No supplemental data for this project. 

 See also the MPD download center for more general data download options.





 




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