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Data set: Dietrich1   (1998)

  Bacillus anthracis lethal toxin susceptibility in females of 50 strains of mice

Study design: baseline survey; 1 cohort.
50 strains tested     female only     Test age: 6-8wks*

  Investigators: Dietrich WF     [More info... papers, citing, funding]

  • Protocol / methods           • Ontology classifications           • Downloads


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immune system — response to bacterial infection — anthrax         in vitro assay  
macrophage susceptibility to Bacillus anthracis
lethal toxin (0=susceptible; 1=resistant) [designation]   Bacillus anthracis lethal toxin      
• all strains  • AKXL only  • BXH only      comparison  
50 strains   age 6-8wks*

Resistant is defined as cells that show greater than 90% viability when incubated 4 hr with lethal factor (LF; 10 micrograms/milliliter) and protective antigen (PA; 1 microgram/milliliter).

Susceptible is defined as cells that show less than 10% viability under the same conditions.

3 updates or corrections were posted since initial release in Dec 2001

Boyden ED, Dietrich WF. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet. 2006 Feb;38(2):240-4. Epub 2006 Jan 22.     PubMed 16429160     MGI

Roberts JE, Watters JW, Ballard JD, Dietrich WF. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. Mol Microbiol. 1998 Jul;29(2):581-91.     PubMed 9720874     MGI

Watters JW, Dewar K, Lehoczky J, Boyartchuk V, Dietrich WF. Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor. Curr Biol. 2001 Oct 2;11(19):1503-11.     PubMed 11591317     MGI

Watters JW, Dietrich WF. Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11. Genomics. 2001 Apr 15;73(2):223-31.     PubMed 11318612     MGI


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