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Project data set: Crabbe4   (2003)

Project Drug study: Measurement of ethanol sensitivity and intoxication using performances in the screen, dowel, and grip strength tests, in 21 inbred strains of mice

An investigation of the pharmacokinetic differences of ethanol intoxication. Blood ethanol concentration (BEC) levels were determined before and after ethanol administration. This project has a complex study design involving multiple cohorts, as described in the protocol workflow table.

Study design: baseline and intervention in various doses; 8 cohorts.
21 strains tested     female male     Test age: various

Investigators Crabbe JC, Metten P, Wahlsten D   [Details, papers]

Protocol View phenotyping protocol and methods

Crabbe4
measurements



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behavior — balance and coordination         dowel balance test  
Crabbe4
latency to fall [s]   ethanol   2g/kg i.p.
        T0:   • 9.5mm    • 15.8mm    • comparison  
        T30:   • 9.5mm    • 15.8mm    • comparison  
8 strains   age 12-16wks
  Inbred
 
behavior — balance and coordination         vertical wire mesh  
Crabbe4
latency to fall from a vertical wire mesh grid 30 min post-injection, screen test   [s]   ethanol   2g/kg i.p.
8 strains   age 9-10wks
  Inbred
 
blood — xenobiotics — alcohol concentration         gas chromatography  
Crabbe4
blood ethanol concentration (BEC), 35 min post-injection, dowel (15.8 mm) test   [mg/mL]   ethanol   2g/kg i.p.
8 strains   age 12-16wks
  Inbred
Crabbe4
blood ethanol levels following grip strength test at various times after treatment [mg/mL]   ethanol   2g/kg i.p.
      time after ethanol:    • 30min  • 60min  • 105min  • 150min    • time comparison  
21 strains   age 7-12wks
  Inbred
 
muscle — skeletal — function         grip strength  
Crabbe4
grip strength test: peak force applied [g]     baseline and  ethanol 2g/kg i.p.
      • baseline  • 30min after ethanol 
      • change (ethanol effect)  • % change (ethanol effect) 
21 strains   age 7-12wks
  Inbred



Number of mice tested per strain, for each measurement

  
Changelog There have been no updates or corrections to the data set since MPD release in Feb 2010  
Reference
Crabbe JC, Cotnam CJ, Cameron AJ, Schlumbohm JP, Rhodes JS, Metten P, Wahlsten D. Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain Behav. 2003 Aug;2(4):201-13.     PubMed 12953786     MGI

Mice
Strain and animal info
Note
Caution: Very low sample sizes (N < 3) are present. [View table]

Crabbe4
downloads


Individual animal data
Table format (.csv)
Individual animal data in table format, with one row per animal and one column per measurement.
Individual animal data
List format (.csv)
Individual animal data organized as one row per animal / measurement reading.
Strain means (.csv) Strain means with SD, N, other summary statistics. One row per strain / sex / measurement.
No supplemental data for this project. 

 See also the MPD download center for more general data download options.





 




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