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Data set: Yuan1   (2007)

  Aging study: IGF-1 and body weight for 33 inbred strains of mice
  Animals were evaluated for serum IGF-1 levels using radioimmunoassay.

Study design: aging study (longitudinal)   1 cohort.
33 strains tested (inbred)     female male     Test age: 6, 12, 18 mo
Sample sizes are 7.0 on average. ... Caution, some N ≤ 2 are present  [details]

  Investigators: Yuan R, Rosen CJ, Beamer WG     [More info... papers, citing, funding]
Jackson Laboratory Nathan Shock Center

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body weight         body weight  
body weight [g]        
• 6mo  • 12mo  • 18mo      age comparison  
33 strains   aging study
endocrine and exocrine — hormones — IGF-1         hormone quantification  
insulin-like growth factor 1 (serum IGF-1) [ng/mL]        
• 6mo  • 12mo  • 18mo      age comparison  
33 strains   aging study

UCLA EMMA GWAS results are available for this project.

One update or correction was posted since initial release in Jun 2008
Leduc MS, Hageman RS, Meng Q, Verdugo RA, Tsaih SW, Churchill GA, Paigen B, Yuan R. Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains. Aging Cell. 2010 Oct;9(5):823-36. doi: 10.1111/j.1474-9726.2010.00612.x.     PubMed 20735370     MGI     FullText

Yuan R, Tsaih SW, Petkova SB, Marin de Evsikova C, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, Rosen CJ, Sundberg JP, Harrison DE, Churchill GA, Paigen B. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell. 2009 Jun;8(3):277-87. Epub 2009 Apr 9.     PubMed 19627267     MGI     FullText

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