Loos2: Sheltering behavior and locomotor activity in males of 11 inbred strains of mice and within-strain variation of 8 of those strains (2016)

Loos M, Koopmans B, Aarts E, Maroteaux G, van der Sluis S; Neuro-BSIK Mouse Phenomics Consortium, Verhage M, Smit AB. Sheltering behavior and locomotor activity in 11 genetically diverse common inbred mouse strains using home-cage monitoring. PLoS One. 2014 Sep 29;9(9):e108563. doi: 10.1371/journal.pone.0108563. eCollection 2014.   PubMed 25264768     FullText


         
This study aimed to determine the aspects of spontaneous mouse homecage behavior that are most influenced by genetic variation. Behavior was recorded for three consecutive days in a home-cage system by 24/7 overhead video tracking for each animal individually. Continuous video-tracking observations of sheltering behavior and locomotor activity were segmented into distinguishable behavioral elements, yielding a set of 115 behavioral parameters which demonstrated high dimensionality. Sixty-seven of those measurements have been accessioned here. Within-strain variation in behavior was also assessed. Selected measurements were log10 transformed by the investigators.

Procedures conducted:
• home cage monitoring  Locomotor activity, sheltering, habituation. 3 day home-cage assessment.

Loos2 downloads
• Download Loos2 project data set     animal data, as uploaded
• Download Loos2 animal data matrix     with factor-related expansion applied as necessary
• Download Loos2 strain means, SD, N, etc.     one row per strain/sex/measure
• Loos2 supplementary data
Investigators Maarten Loos       Sylics,  Amsterdam NETHERLANDS
Bastijn Koopmans       Sylics,  Amsterdam NETHERLANDS
Participants Aarts E, Maroteaux G, van der Sluis S, Verhage M, Smit AB, Neuro-BSIK Mouse Phenomics Consortium
ContactMaarten Loos     maarten.loos@sylics.com     Lab web site
AcknowledgementsFunding provided by Agentschap NL (NeuroBSIK Mouse Phenomics Consortium, BSIK03053); NeuroBasic PharmaPhenomics Consortium (LSH framework FES0908); Netherlands Organization for Scientific Research (NWO/MaGW: VIDI-452-12-014)
Project type Phenotype strain survey data set
MPD identifiersLoos2     MPD:540
Data changelog No updates/corrections.       Initial release date: 04/2016.
Formatted citation
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Mice: inbred w/CC7   11 strains   ♂   age 8-12wks   1 experimental group

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Data set
Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
Panel
No. of Strains
Sex
Age
Sample Size (Avg)
    Loos2 home cage monitoring (none) cumulative number of activity bouts, over 3 days of testing, log10 transformed   [log(n)]  activity_num   54001     dark    light inbred w/CC7 11 m 8-12wks N=40
    Loos2 home cage monitoring (none) cumulative duration of activity during dark phase, over 3 days of testing   [s]  activity_dur_DK   54003 inbred w/CC7 11 m 8-12wks N=40
    Loos2 home cage monitoring (none) cumulative duration of activity during light phase, over 3 days of testing, log10 transformed   [log(s)]  activity_dur_LT   54004 inbred w/CC7 11 m 8-12wks N=40
    Loos2 home cage monitoring (none) mean duration per activity bout, over 3 days of testing, log10 transformed   [log(s)]  activity_mean_dur   54005     dark    light inbred w/CC7 11 m 8-12wks N=40
    Loos2 home cage monitoring (none) habituation ratio describing change in cumulative activity duration, over 3 days of testing, log10 transformed   [log(ratio)]  activity_dur_hab   54007     dark    light inbred w/CC7 11 m 8-12wks N=40
    Loos2 home cage monitoring (none) dark-light index describing difference in cumulative activity duration between light and dark phase, over 3 days of testing   [ratio]  activity_dur_DKLT_index   54011 inbred w/CC7 11 m 8-12wks N=40
    Loos2 home cage monitoring (none) cumulative duration in spout zone, over 3 days of testing, log10 transformed   [log(s)]  spout_dur   54012 inbred w/CC7 11 m 8-12wks N=40
    Loos2 home cage monitoring (none) cumulative duration in feeding zone during dark phase, over 3 days of testing, log10 transformed   [log(s)]  feeding_dur_DK   54014 inbred w/CC7 11 m 8-12wks N=40
    Loos2 home cage monitoring (none) feeding zone, duration   [s]  feeding_dur_LT   54015 inbred w/CC7 11 m 8-12wks N=40
    Loos2 home cage monitoring (none) cumulative number of visits to OnShelter zone, over 3 days of testing, log10 transformed   [log(n)]  onshelter_num   54016     dark    light inbred w/CC7 11 m 8-12wks N=40
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