MPD: Data set: Bailey1

Bailey1: Identification of QTL for locomotor activation and anxiety using related inbred strains C57BL/6J and C58/J (2008)

Bailey JS, Grabowski-Boase L, Steffy BM, Wiltshire T, Churchill GA, Tarantino LM. Identification of quantitative trait loci for locomotor activation and anxiety using closely related inbred strains. Genes Brain Behav. 2008 Oct;7(7):761-9. PubMed 19130624

An intercross of similar inbred mouse strains, C57BL/6J and C58/J, was carried out as a control cross for a mutagenesis mapping study in behavior research. The authors identified significant QTL in F2 progeny. The locus on Chr 8 and its interaction effect form the core set of QTL controlling activation and anxiety behaviors, with additional loci on Chr 1 and 6 present in a subset of the behaviors. Mice were assessed using the open field test.

Note on studied population: C57BL/6J and C58/J

Procedures conducted:

• study archive

Open field test. Locomotor activity, anxiety-related behavior.

Bailey1 downloads
QTL projects have several available downloads.
Use the QTL Data Downloads button near the bottom of this page.

Ontology terms mapped to Bailey1 measures:

MP:0001362 abnormal anxiety-related response
MP:0001392 abnormal locomotor behavior
MP:0013189 abnormal exploration in a new environment
VT:0001392 locomotor behavior trait
VT:0010471 exploratory behavior trait
VT:0010716 anxiety-related behavior trait

Investigators	J S Bailey Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Grabowski-Boase L, Steffy BM, Wiltshire T, Tarantino LM
Contact	Gary A Churchill gary.churchill@jax.org
Affiliated Center	QTL Archive
Acknowledgements	Research described in this article was supported by a Novartis Grant SFP-1407 and funding from the NIH NIDA Grant DA 022392 to L.M.T.
Project type	QTL Archive data set
MPD identifiers	Bailey1 MPD:207
Data changelog	No updates/corrections. Initial release date: 10/2009.

QTL data set parameters:

Progenitor strains	C57BL/6J C58/J
Cross direction notation	(B6xC58/J) F1 x (B6xC58/J) F1
Cross type	F2 intercross
Population size	196 ♀ 166 ♂
Age	8wks

Measured phenotypes: To access these data use the QTL Data Downloads button at bottom of page.

Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Bailey1	open field test	(none)	percentage of time spent in center of arena (interval of 10 min) [%] PCTT10 20701	QTL population	both	8wks	N=181

Bailey1	open field test	(none)	total distance [cm] TOTDIST 20702	QTL population	both	8wks	N=181

Bailey1	open field test	(none)	total rearing [n] TOTREAR 20703	QTL population	both	8wks	N=181

Bailey1	open field test	(none)	ambulatory episodes [n] AMBEPIS 20704	QTL population	both	8wks	N=181

Bailey1	open field test	(none)	average velocity [cm/sec] AVGVELO 20705	QTL population	both	8wks	N=181

Bailey1	open field test	(none)	percentage of time resting [%] PCTREST 20706	QTL population	both	8wks	N=181

Bailey1	open field test	(none)	activity factor ACTFACT 20707	QTL population	both	8wks	N=181

Bailey1	open field test	(none)	anxiety factor ANXFACT 20708	QTL population	both	8wks	N=181

Associated genomic features

MGI-curated QTL / genomic features that have been associated with this data set:
Lacanx1 Lacanx2 Lacanx3 Lacanx4

Project / data set: Bailey1 a.k.a. Bailey_2008
Excel file: Data_Description_B6xC58J_Bailey2008.xlsx
CSV file: Bailey2008_B6xC58J_B37_Data.csv
Readme / text file: ._readme.txt
Readme / text file: readme_Bailey2008.txt
QC plots, figures, etc.: QCReport_Bailey2008.pdf