Stylianou2: HDL in B6.A consomic and F2 mouse crosses (2006)

Stylianou IM, Tsaih SW, DiPetrillo K, Ishimori N, Li R, Paigen B, Churchill G. Complex genetic architecture revealed by analysis of high-density lipoprotein cholesterol in chromosome substitution strains and F2 crosses. Genetics. 2006 Oct;174(2):999-1007. Epub 2006 Sep 1.   PubMed 16951076  


       
This project is to examine the genetic architecture underlying plasma high-density lipoprotein cholesterol (HDL) levels in the C57BL/6J (B) and A/J (A) mouse strains. We compared the QTL results of HDL in a classical F2 intercross with three chromosome (chr3, 8 and 11) substitution strains (CSS) intercrosses. For detailed protocols see Stylianou et al Genetics (2006; 174: 999-1007).

Note on studied population: B6.A consomic and F2 mouse crosses

Procedures conducted:
• study archive  Lipids. Cholesterol, triglycerides, body weight.

Stylianou2 downloads
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Use the QTL Data Downloads button near the bottom of this page.
Investigators Ioannis M Stylianou       Xenon Pharmaceuticals,  Burnaby, British Columbia CANADA
Gary A Churchill       The Jackson Laboratory,  Bar Harbor, ME
Participants Tsaih SW, DiPetrillo K, Ishimori N, Li R, Paigen B
ContactGary A Churchill     gary.churchill@jax.org
Affiliated CenterQTL Archive
AcknowledgementsThis work was supported by The American Heart Association grant 0525816T and the National Institutes of Health grants HL77796 (to B.J.P) and GM070683 (to G.C).
Project type QTL Archive data set
MPD identifiersStylianou2     MPD:185
Data changelog No updates/corrections.       Initial release date: 02/2011.
QTL data set parameters:
Dataset 1: B6 x A/J       Stylianou2
Progenitor strains A/J     C57BL/6J    
Cross direction notation(B6xA) F1 x (B6xA) F1
Cross typeF2 intercross
Population size 271 ♀     343 ♂

Progenitor strains B6.A-Chr3     C57BL/6J    
Cross typeNone
Population size None ♀     None ♂

Progenitor strains B6.A-Chr8     C57BL/6J    
Cross typeNone
Population size None ♀     None ♂

Progenitor strains B6.A-Chr11     C57BL/6J    
Cross typeNone
Population size None ♀     None ♂


Measured phenotypes:       To access these data use the QTL Data Downloads button at bottom of page.

Associated genomic features
MGI-curated QTL / genomic features that have been associated with this data set:
Hdlq15   Hdlq40   Hdlq41   Hdlq42   Hdlq43   Hdlq44   Hdlq45   Hdlq46   Hdlq47   Hdlq48   Hdlq49   Hdlq50   Hdlq51  


Dataset 1: B6 x A/J     Stylianou2     a.k.a. Stylianou_2006b
Excel file:   Data_Description_B6xA_Stylianou2006b.xlsx
CSV file:   Stylianou2006b_B6xA_B37_Data.csv
Readme / text file:   readme_Stylianou2006b.txt

Project / data set:   Stylianou2c     a.k.a. None

QTL file list not available on this MPD instance.

Project / data set:   Stylianou2d     a.k.a. None

QTL file list not available on this MPD instance.

Project / data set:   Stylianou2e     a.k.a. None

QTL file list not available on this MPD instance.