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DBA/1LacJ

What Does This Nomenclature Mean?
Strain #:001140
RRID:IMSR_JAX:001140Info
Common Name: DBA1 Lac | Also Known As: D1Lac
DBA/1LacJ mice have been widely used in studies of collagen-induced arthritis, although recent in-house studies suggest that the response to collagen induction in the DBA/1LacJ strain is not as robust as indicated by earlier studies. DBA substrains of mice, derived from DBA which is the oldest inbred strain of mice, have been widely used in many areas of research including age-related hearing loss.
Important Note: This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age.
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Cryo RecoveryCryo-Recovered Mouse
Frozen EmbryoFrozen Mouse Embryo
#001140
Homozygous for Cdh23ahl
1 pair minimum
Mice Available In 12 Weeks.Contact Customer Service for more information.
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WHAT TO EXPECT
  • A confirmation will be sent after order placement.
  • Typically, eight or more animals are produced.
  • The total number, sex and genotypes will be provided to you prior to scheduling shipment.
  • Additional breeding may be required to produce the genotype(s) of interest
  • If we fail to produce the animals of the correct genotype, you will not be charged, unless this is designated as "fee for service" project

How it's Made

Strain Highlights
Strain Type
Inbred Strain
Originating Article
Originating Article
Info When using the DBA1 Lac mouse strain in a publication, please include JAX stock #001140 in your Materials and Methods section.

Detailed Description
Historical reports indicate DBA/1J and DBA/1LacJ mice immunized with type II collagen develop a severe polyarthritis mediated by an autoimmune response. Recent in-house studies suggest that the response to collagen induction in the DBA/1LacJ strain is not as robust as indicated by earlier studies. Arthritis models such as B10.RIII-H2r H2-T18b/(71NS)SnJ (Stock No. 000457) and BUB/BnJ (Stock No. 000653) can be used as alternatives to DBA/1LacJ. Similar to the human condition, mice with collagen-induced arthritis display synovitis and erosions of cartilage and bone. In addition, susceptibility in both humans and mice is linked to the expression of specific MHC class II molecules. DBA/1 mice show a low susceptibility to developing atherosclerotic aortic lesions (20 to 350 um2 atherosclerotic aortic lesions/aortic cross-section) following 14 weeks on an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat).

Development
The DBA inbred strain is the oldest of all inbred strains of mice. Dr. CC Little began inbreeding in 1909 from a mouse colony segregating for coat color. During 1929 and 1930 crosses were made among substrains, and several new substrains were established including DBA/1 and DBA/2. DBA/1 and DBA/2 differ at a large number of loci (including the MHC H2 haplotype) which most likely results from residual heterozygosity in the strain when the substrains were separated.

In 1955, mice were transfered from The Jackson Laboratory to Laboratory Animal Center (Lac), Carshalton, UK. In 1981, embryos from the Frozen Embryo Bank at Lac were sent to Les at The Jackson Laboratory.


Genetics
Genetic Background
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Generation
Generation Definitions >
F123p
(Last Updated: May 10th 2019)
Allele Symbol Cdh23ahl ExternalLink
Allele Name
age related hearing loss 1
Gene Symbol
Cdh23
Allele Type
Spontaneous
Gene Name
cadherin 23 (otocadherin)
Gene Synonym(s)
4930542A03Rik,ahl,bob, ... 4930542A03Rik, ahl, bob, CDHR23, mdfw, nmf112, nmf181, nmf252, PITA5, sals, USH1D,
Site of Expression
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Expressed Gene(s)
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Strain of Origin
multiple strains
Chromosome
10
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How it's Used

References
2004
Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse.
Petkov PM , et al.
PubMed:15081119
MGI:J:89298
Genomics 83(5):902-11

1999
Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice.
McIndoe RA , et al.
PubMed:10051620
MGI:J:53356
Proc Natl Acad Sci U S A 96(5):2210-4

1997
Collagen-induced arthritis, an animal model of autoimmunity.
Myers LK , et al.
PubMed:9364191
MGI:J:109904
Life Sci 61(19):1861-78

1996
Arthritis in mice induced by a single immunisation with collagen.
Kato F , et al.
PubMed:8774181
MGI:J:109907
Ann Rheum Dis 55(8):535-9

1980
Immunisation against heterologous type II collagen induces arthritis in mice.
Courtenay JS , et al.
PubMed:6153460
MGI:J:24763
Nature 283(5748):666-8

When using the DBA1 Lac mouse strain in a publication, please include JAX stock #001140 in your Materials and Methods section.
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