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LG/J

What Does This Nomenclature Mean?

Strain #:000675

RRID:IMSR_JAX:000675

Common Name: Large

LG/J mice develop antinuclear antibodies and rheumatoid factor as well as renal disease characterized by glomerulonephritis, interstitial nephritis, and perivasculitis. LG/J mice are often compared to SM/J (Stock No. 000687) for quantitative trait locus analysis in the areas of atherosclerosis, obesity, and mandible size . These mice are susceptible to diet-induced obesity and diet-induced atherosclerosis. This strain is among the least responsive to phytohemagglutinin.

Important Note: This strain is homozygous for Cdh23^ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age.

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Quantity

Genotypeinbred

Price$3,532.00

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1 pair minimum

Availability

Mice Available In 12 Weeks.Contact Customer Service for more information.

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Details

A confirmation will be sent after order placement.
Typically, eight or more animals are produced.
The total number, sex and genotypes will be provided to you prior to scheduling shipment.
Additional breeding may be required to produce the genotype(s) of interest
If we fail to produce the animals of the correct genotype, you will not be charged, unless this is designated as "fee for service" project

How it's Made

Inbred Strain

Originating Article

Browse References >

LG/J mice develop antinuclear antibodies and rheumatoid factor as well as renal disease characterized by glomerulonephritis, interstitial nephritis, and perivasculitis (Peng et al., 1996). LG/J was the predominant strain used to develop the MRL/LpJ (Stock No. 000486) inbred strain, a model for autoimmunity. LG/J mice are often compared to SM/J (Stock No. 000687) for quantitative trait locus analysis in the areas of atherosclerosis, obesity, and mandible size . These mice are susceptible to diet-induced obesity and diet-induced atherosclerosis. This strain is among the least responsive to phytohemagglutinin (Heiniger et al., 1975).

Developed by Goodale with selection for large body size begining in 1931. Inbred by M.N. Runner. Two substrains, J and Ckc, were separated at F27.

Genetic Background
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Generation
Generation Definitions >

(Last Updated: August 23rd 2019)

Allele Symbol Cdh23^ahl

Allele Name

Gene Symbol

Allele Type

Gene Name

Gene Synonym(s)

Site of Expression

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Expressed Gene(s)

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Strain of Origin

Chromosome

Molecular Note

Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has shown this is caused by a G-to-A transition at coding nucleotide position 753 of Cdh23 (SNP rs257098870) at the 3' end of exon 7 (in ENSMUST00000073242). This hypomorphic allele changes splice donor site G-GT to A-GT, causing skipping of out-of-frame exon 7. This is predicted to delete part of the 2nd and 3rd ectodomains in the encoded peptide and cause reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD-1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: 129S1/SvImJ, C3H/HeSnJ, I/LnJ, YBR/Ei, MRL/MpJ.

General Note

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Mutations Made By

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Allele Symbol Ahr^d

Allele Name

Gene Symbol

Allele Type

Gene Name

Gene Synonym(s)

Site of Expression

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Expressed Gene(s)

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Strain of Origin

Chromosome

Molecular Note

This allele encodes a 104 kDa receptor that is stabilized by molybdate and has an affinity for ligand 10-100 fold lower than that of the receptor produced by the C57BL/6J allele. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, an apparent T to C transition replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the DBA/2J allele. This change would extend translation of the DBA/2J mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa vs 95 kDa for the C57BL/6J allele). A second T to C transition changes a leucine codon in the C57BL/6J allele to a proline codon in the DBA/2J allele, and would likely change secondary structure of the peptide and thus ligand affinity.

General Note

Strain of origin - this allele was found in DBA/2J, AKR/J, 129, SWR, RF, NZB strains

Mutations Made By

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Allele Symbol Gpr84^del

Allele Name

Gene Symbol

Allele Type

Gene Name

Gene Synonym(s)

Site of Expression

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Expressed Gene(s)

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Strain of Origin

Chromosome

Molecular Note

This spontaneously arising frameshift deletion is located in exon 2 at position 103308576 bp (NCBI Build 37) and results in a premature stop codon. The mutation is predicted to result in a truncated protein lacking the transmembrane domains 4-7. The inbred strains BDP/J, DBA/1J, DBA/2J, I/LnJ, FVB/NJ, LG/J, MRL/MpJ, NODShi/LtJ, NOR/LtJ, P/J, PL/J, SKHIN/Sprd, SJL/J, SM/J are homozygous for the deletion. The allele is segregating in the outbred stocks ICR and CD-1.

General Note

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Mutations Made By

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How it's Used

Festing Inbred Strain Characteristics: LG

Mouse Phenome Database

Selected References

Additional References

Allele References

2004

Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse.
Petkov PM , et al.

PubMed:15081119
MGI:J:89298
Genomics 83(5):902-11

2003

Diet, obesity, and hyperglycemia in LG/J and SM/J mice.
Ehrich TH , et al.

PubMed:14627762
MGI:J:86873
Obes Res 11(11):1400-10

1949

Selection for Small and Large Body Size in the House Mouse.
Macarthur JW , et al.

PubMed:17247310
MGI:J:2452
Genetics 34(2):194-209

1944

Genetics of body size and related characters.
Macarthur JW , et al.

PubMed:
MGI:J:25351
Am Naturalist 78:142-57

When using the Large mouse strain in a publication, please include JAX stock #000675 in your Materials and Methods section.

Husbandry

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Facility Barrier Level Descriptions >

G200 (Maximum)

Sibling x Sibling

Coat Color

Coat Color Guide >

Albino

Details

albino
Related Genotype: a/a Tyr^c/Tyr^c

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The Jackson Laboratory ensures the genetic quality and genotyping of JAX® Mice strains before making them available to researchers. However, phenotypes may vary due to environmental conditions and may not be fully characterized. Phenotype descriptions are based on published data, and JAX does not guarantee phenotype or breeding performance.

To ensure JAX® Mice meet your research needs, we recommend:

Genotyping mutant mice upon arrival.
Performing pilot experiments on a small number of mice.
Ordering more than one breeding pair to establish your colony and avoid delays.

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