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C57BL/6J-mtPWD/Ph/ForeJ

What Does This Nomenclature Mean?
Strain #:005761
RRID:IMSR_JAX:005761Info
Common Name: B6.PWD-mt
The mitochondrial genome from PWD/Ph has been introduced into C57BL/6J in this conplastic strain with C57BL/6J as background.
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Cryo RecoveryCryo-Recovered Mouse
Frozen EmbryoFrozen Mouse Embryo
#005761
Homozygous
$3,532.00
2 carriers minimum
Mice Available In 12 Weeks.Contact Customer Service for more information.
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WHAT TO EXPECT
  • A confirmation will be sent after order placement.
  • Typically, eight or more animals are produced.
  • The total number, sex and genotypes will be provided to you prior to scheduling shipment.
  • Additional breeding may be required to produce the genotype(s) of interest
  • If we fail to produce the animals of the correct genotype, you will not be charged, unless this is designated as "fee for service" project

How it's Made

Strain Highlights
Strain Type
Conplastic
Originating Article
Originating Article
Info When using the B6.PWD-mt mouse strain in a publication, please cite the originating article(s) and include JAX stock #005761 in your Materials and Methods section.

Detailed Description
This strain represents one of a panel of inter-species chromosome substitution (or consomic) strains (IC-ISS). Each strain carries a chromosome from the Mus musculus musculus wild-derived strain PWD/Ph introgressed into a Mus musculus domesticus C57BL/6J background. The two species are believed to have diverged 350,000 to one million years ago and exhibit multiple genetic and phenotypic differences. The strain set also includes a conplastic strain (mtPWD/Ph) created by sequential backcrossing of the donor female to the host male. A conplastic strain carries the mitochondrial genome of the donor strain. The IC-ISS strains represent a tool for dissection of quantitative trait loci.

Development
Dr. Jiri Forejt from The Institute of Molecular Genetics, Prague, Czech Republic developed the C57BL/6J-mtPWD/Ph/ForeJ conplastic strain by sequential backcrossing of the PWD/Ph donor female to the C57BL/6J host male (See SNP note below). A conplastic strain carries the mitochondrial genome of the donor strain. The set was donated to The Jackson Laboratory in 2005.

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 1 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.


Genetics
Genetic Background
000664 C57BL/6J
Generation
Generation Definitions >

(Last Updated: March 9th 2011)

How it's Used

JAX Physiological Data


References
2008
Mouse consomic strains: exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies.
Gregorova S , et al.
PubMed:18256238
MGI:J:130871
Genome Res 18(3):509-15

When using the B6.PWD-mt mouse strain in a publication, please cite the originating article(s) and include JAX stock #005761 in your Materials and Methods section.

Husbandry

Suggested Controls

Genotyping Protocols
Genotyping Resources and Troubleshooting >
No molecular genotyping assay is available for this strain. A visible phenotype can be used to confirm the genotype of animals from this strain. Progeny testing may be required to produce animals with a phenotype.

Animal Health Reports

Breeding Considerations
Additional Breeding and Husbandry Support >
When maintaining a live colony, homozygous mice may be bred together.

Appearance
Black
Details

black
Related Genotype: a/a