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C57BL/6J-Chr 12PWD/Ph/ForeJ

What Does This Nomenclature Mean?
Strain #:005263
RRID:IMSR_JAX:005263Info
Common Name: B6.PWD-Chr12
Chromosome 12 from PWD/Ph has replaced the homologous chromosome of C57BL/6J in this strain of the set of consomic strains with C57BL/6J as background.
Important Note: This member of the strain set is homozygous for a small C57BL/6J region in the donor chromosome. The region is identified with the SNP markers rs3686631-3696039.
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Cryo RecoveryCryo-Recovered Mouse
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#005263
Consomic
2 carriers minimum
Mice Available In 12 Weeks.Contact Customer Service for more information.
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WHAT TO EXPECT
  • A confirmation will be sent after order placement.
  • Typically, eight or more animals are produced.
  • The total number, sex and genotypes will be provided to you prior to scheduling shipment.
  • Additional breeding may be required to produce the genotype(s) of interest
  • If we fail to produce the animals of the correct genotype, you will not be charged, unless this is designated as "fee for service" project
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How it's Made

Strain Highlights
Strain Type
Consomic
Terms Of UseAdditional Use Restrictions Apply
Originating Article
Originating Article
Info When using the B6.PWD-Chr12 mouse strain in a publication, please cite the originating article(s) and include JAX stock #005263 in your Materials and Methods section.
Detailed Description
This strain represents one of a panel of inter-species chromosome substitution (or consomic) strains (IC-ISS). Each strain carries a chromosome from the Mus musculus musculus wild-derived strain PWD/Ph introgressed into a Mus musculus domesticus C57BL/6J background. The two species are believed to have diverged 350,000 to one million years ago and exhibit multiple genetic and phenotypic differences. The strain set also includes a conplastic strain (mtPWD/Ph) created by sequential backcrossing of the donor female to the host male. A conplastic strain carries the mitochondrial genome of the donor strain. The IC-ISS strains represent a tool for dissection of quantitative trait loci.
Development
Dr. Jiri Forejt from The Institute of Molecular Genetics, Prague, Czech Republic developed the C57BL/6J-Chr #PWD/Ph/ForeJ strain set by replacing individual chromosomes from the PWD/Ph donor strain into the C57BL/6J host strain using a marker-assisted series of backcrosses. The set was donated to The Jackson Laboratory in 2005.
Genetics
Genetic Background
000664 C57BL/6J
Generation
Generation Definitions >
F3p
(Last Updated: January 4th 2006)

How it's Used

JAX Physiological Data
Mouse Phenome DatabaseExternalLink

References
2008
Mouse consomic strains: exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies.
Gregorova S , et al.
PubMed:18256238
MGI:J:130871
Genome Res 18(3):509-15
When using the B6.PWD-Chr12 mouse strain in a publication, please cite the originating article(s) and include JAX stock #005263 in your Materials and Methods section.
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