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BXD63/RwwJ

What Does This Nomenclature Mean?
Strain #:007108
RRID:IMSR_JAX:007108Info
The BXD#/Rww recombinant inbred (RI) strains originate from crosses between C57BL/6J (000664) females and DBA/2J (000671) males and were generated using a strategy of advanced intercrosses (AI). They may be used to study the genetics of behavioral phenotypes (including alcohol and drug addiction, stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).
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Cryo RecoveryCryo-Recovered Mouse
#007108
Inbred
1 pair minimum
Mice Available In 12 Weeks.Contact Customer Service for more information.
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WHAT TO EXPECT
  • A confirmation will be sent after order placement.
  • Typically, eight or more animals are produced.
  • The total number, sex and genotypes will be provided to you prior to scheduling shipment.
  • Additional breeding may be required to produce the genotype(s) of interest
  • If we fail to produce the animals of the correct genotype, you will not be charged, unless this is designated as "fee for service" project
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How it's Made

Strain Highlights
Strain Type
Recombinant Inbred (RI)
Terms Of UseAdditional Use Restrictions Apply
Originating Article
Originating Article
Info When using the BXD63/RwwJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #007108 in your Materials and Methods section.
Detailed Description
The BXD recombinant inbred (RI) strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. The BXD set of RI strains also are used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density.

The BXD#/Rww set was generated using a strategy of advanced intercrosses (AI). The AI technique produces recombinant RI strains which incorporate approximately twice as many recombinations as the standard RI strains. The addition of the AI BXD RI lines to the existing BXD set creates the largest of the mouse RI mapping panels. This set is useful in QTL mapping and analysis of gene function.

The strain distribution pattern (SDP) for the BXD RI strains is available through the Mouse Genome Informatics Contributed Data Sets and Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network .

Development
The BXD#/Rww advanced recombinant inbred (ARI) lines are derived from two independently derived advanced intercrosses between the C57BL/6J and DBA/2J progenitor strains generated at Princeton University and the University of Tennessee. Crosses at Princeton were intiated using B6D2F1/J mice crossed to generate B6D2F2 mice. These mice were randomly mated to generate a G3 population. Subsequent matings were chosen to minimize the number of common parents. AIL from the Tennessee crosses were initiated with reciprocal crosses of the parental strains. As a result, mice from the Tennessee set can have the Y chromosome and mitochondrial genome from either progenitor. Mice from the Princeton set have a Y chromosome from DBA/2J and the mitochondrial genome from C57BL/6J. All ARI lines were intercrossed for 9-14 generations before inbreeding. Like the Princeton crosses, the Tennessee crosses also sought to miminize common ancestors in each cross although fewer breeding cages per generation were used. As of early 2007, most lines were inbred for more than 20 generations.

The lines were donated to The Jackson Laboratory Repository in 2007 by Dr. Robert Williams.

Genetics
Genetic Background
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Generation
Generation Definitions >
F39p
(Last Updated: January 30th 2015)
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