The BXD recombinant inbred (RI) strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. The BXD set of RI strains also are used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density.The BXD#/Rww set was generated using a strategy of advanced intercrosses (AI). The AI technique produces recombinant RI strains which incorporate approximately twice as many recombinations as the standard RI strains. The addition of the AI BXD RI lines to the existing BXD set creates the largest of the mouse RI mapping panels. This set is useful in QTL mapping and analysis of gene function.The strain distribution pattern (SDP) for the BXD RI strains is available through the Mouse Genome Informatics <a href=" http://www.informatics.jax.org/downloads/datasets/index.html#MGIRI" target="_blank"> Contributed Data Sets</a> and <a href=" http://gn2.genenetwork.org/" target="_blank"> Gene Network</a>. Additional tools and information are presented through the Mouse Phenome Database <a href=" http://phenome.jax.org/panels/BXD" target="_blank"> Specialized Strain Panel Query Form</a>, and <a href=" http://www.genenetwork.org/mouseCross.html" target="_blank"> Gene Network</a>. The Jackson Laboratory live colony was a challenging breeder / very poor breeder. It exhibited a high incidence of non-productive matings and when productive, the litters were small [May 2021]. See our <a href="https://www.jax.org/jax-mice-and-services/customer-support/technical-support/breeding-and-husbandry-support/general-husbandry-tips">General Husbandry Tips</a>.

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In May 2021, Stock No. 007105 was discontinued due to very poor breeding and difficulty with cryopreservation. Please search the <a href="https://mice.jax.org/">JAX&reg; Mice database</a> for other strains which may be suitable for your studies, or contact <a href="https://www.jax.org/jax-mice-and-services/customer-support/technical-support">Technical Support</a> for assistance. The BXD#/Rww recombinant inbred (RI) strains originate from crosses between C57BL/6J (Stock No. <a href="https://www.jax.org/strain/000664">000664</a>) females and DBA/2J (Stock No. <a href="https://www.jax.org/strain/000671">000671</a>) males and were generated using a strategy of advanced intercrosses (AI). They may be used to study the genetics of behavioral phenotypes (including alcohol and drug addiction, stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).

Please contact <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support/technical-support/contact-technical-support-form">Technical Support</a> for more information.