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Cryo RecoveryCryo-Recovered Mouse
Frozen EmbryoFrozen Mouse Embryo
#002065
Inbred
2 pair minimum
Mice Available In 12 Weeks.Contact Customer Service for more information.
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WHAT TO EXPECT
  • A confirmation will be sent after order placement.
  • Typically, eight or more animals are produced.
  • The total number, sex and genotypes will be provided to you prior to scheduling shipment.
  • Additional breeding may be required to produce the genotype(s) of interest
  • If we fail to produce the animals of the correct genotype, you will not be charged, unless this is designated as "fee for service" project

How it's Made

Strain Highlights
Strain Type
Inbred Strain
Originating Article
Originating Article
Info When using the 129T2/SvEmsJ mouse strain in a publication, please include JAX stock #002065 in your Materials and Methods section.

Detailed Description
Historically, the 129 inbred mice are known for the high incidence of spontaneous testicular teratomas, though the incidence differs between substrains. (1-3% in 129 parental substrains; 30% in teratoma substrains.) More recently 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. There is major genetic variation within the 129 "family", which has led to an update of the nomenclature and a division of the substrains into three major groups: parental substrains (129P), steel substrains (129S) and "teratoma" substrains (129T).

The teratoma family of 129 sublines was derived from an outcross of the parental 129/Sv to a hybrid (WC x C57BL/6) to introduce the dominant spotting mutation (KitW). After 8 generations of backcrossing to 129/Sv a higher incidence of testicular teratomas was observed. The subline became the 129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J substrain (Stock No. 000091). In 1992 E.M. Simpson selected against the ter allele to establish the present substrain which was transferred to the Jackson Laboratory in 1993.

Investigators using 129 substrains for targeted mutagenesis should be careful in the selection of the appropriate 129 substrain to match the embryonic stem cell line. For a complete history of the numerous 129 substrains, see Simpson, et al., 1997.

Development
Derived from strain 129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J (Stock No. 000091) and selected for the wild type of the Dnd1Ter by E.M. Simpson in 1992.

Genetics
Genetic Background
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Generation
Generation Definitions >
F102pF1+
(Last Updated: May 24th 2024)
Allele Symbol Disc1del ExternalLink
Allele Name
deletion
Gene Symbol
Disc1
Allele Type
Spontaneous
Gene Name
disrupted in schizophrenia 1
Gene Synonym(s)
C1orf136,SCZD9,
Site of Expression
---
Expressed Gene(s)
---
Strain of Origin
various
Chromosome
8
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Allele Symbol Aw ExternalLink
Allele Name
white-bellied agouti
Gene Symbol
a
Allele Type
Spontaneous
Gene Name
nonagouti
Gene Synonym(s)
agouti,agouti signal protein,AGSW, ... agouti, agouti signal protein, AGSW, AGTI, AGTIL, As, Asip, ASP, SHEP9,
Site of Expression
---
Expressed Gene(s)
---
Strain of Origin
Not Specified
Chromosome
2
More
Allele Symbol Tyrc-ch ExternalLink
Allele Name
chinchilla
Gene Symbol
Tyr
Allele Type
Spontaneous
Gene Name
tyrosinase
Gene Synonym(s)
ATN,CMM8,Oca1, ... ATN, CMM8, Oca1, OCA1A, OCAIA, SHEP3, skc35,
Site of Expression
---
Expressed Gene(s)
---
Strain of Origin
fancier's stock
Chromosome
7
More
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