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BXD27/TyJ
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- How it's Made
- How it's Used
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BXD27/TyJ
What Does This Nomenclature Mean?
Strain #:000041
RRID:IMSR_JAX:000041
The BXD set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes. The BXD strains are derived from the C57BL/6J (Stock No. 000664) and DBA/2J (Stock No. 000671) progenitor strains.
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Cryo-Recovered Mouse#000041
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Details
WHAT TO EXPECT
- A confirmation will be sent after order placement.
- Typically, eight or more animals are produced.
- The total number, sex and genotypes will be provided to you prior to scheduling shipment.
- Additional breeding may be required to produce the genotype(s) of interest
- If we fail to produce the animals of the correct genotype, you will not be charged, unless this is designated as "fee for service" project
How it's Made
Strain Highlights
Recombinant Inbred (RI)
Originating Article When using the BXD27/TyJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #000041 in your Materials and Methods section.
When using the BXD27/TyJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #000041 in your Materials and Methods section.Detailed Description
The BXD RI strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. The BXD set of RI strains also is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density.
The strain distribution pattern (SDP) for the BXD RI strains is available through the Mouse Genome Informatics Contributed Data Sets and Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network.
The Jackson Laboratory live colony was a challenging breeder / very poor breeder. It exhibited a high incidence of non-productive matings and when productive, the litters were small [May 2021]. See our General Husbandry Tips.
Development
The BXD set of RI strains was developed in the laboratory of Benjamin Taylor and was transferred to The Jackson Laboratory from Dr. Taylor's research colony upon his retirement. Of 42 BXD RI strains originally derived from the C57BL/6J (Stock No. 000664) and DBA/2J (Stock No. 000671), a number have become extinct over the years. The other BXD RI strains now being distributed are listed under "Related Recombinant Inbred Strains."
Genetics
Genetic Background
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Generation
Generation Definitions >
[[p]F53p]
(Last Updated: December 11th 1992)
Generation Definitions >
[[p]F53p]
(Last Updated: December 11th 1992)
How it's Used
JAX Physiological Data
References
Selected References
Additional References
2021
A platform for experimental precision medicine: The extended BXD mouse family.
Ashbrook DG , et al.
Ashbrook DG , et al.
PubMed:33472028
MGI:J:314802
Cell Syst 12(3):235-247.e9
MGI:J:314802
Cell Syst 12(3):235-247.e9
2000
Quantitative trait loci affecting ethanol sensitivity in BXD recombinant inbred mice.
Browman KE , et al.
Browman KE , et al.
PubMed:10656187
MGI:J:66463
Alcohol Clin Exp Res 24(1):17-23
MGI:J:66463
Alcohol Clin Exp Res 24(1):17-23
1999
Provisional QTL for circadian period of wheel running in laboratory mice: quantitative genetics of period in RI mice.
Hofstetter JR , et al.
Hofstetter JR , et al.
PubMed:10373097
MGI:J:55774
Chronobiol Int 16(3):269-79
MGI:J:55774
Chronobiol Int 16(3):269-79
1998
Provisional mapping of quantitative trait loci for chronic ethanol withdrawal severity in BXD recombinant inbred mice.
Crabbe JC , et al.
Crabbe JC , et al.
PubMed:9655868
MGI:J:49185
J Pharmacol Exp Ther 286(1):263-71
MGI:J:49185
J Pharmacol Exp Ther 286(1):263-71
1998
Quantitative trait loci affecting peak bone mineral density in mice.
Klein RF , et al.
Klein RF , et al.
PubMed:9797472
MGI:J:50828
J Bone Miner Res 13(11):1648-56
MGI:J:50828
J Bone Miner Res 13(11):1648-56
1998
Localization of genes mediating acute and sensitized locomotor responses to cocaine in BXD/Ty recombinant inbred mice.
Phillips TJ , et al.
Phillips TJ , et al.
PubMed:9526019
MGI:J:46922
J Neurosci 18(8):3023-34
MGI:J:46922
J Neurosci 18(8):3023-34
1998
Genetic dissection of testicular weight in the mouse with the BXD recombinant inbred strains.
Zidek V , et al.
Zidek V , et al.
PubMed:9657844
MGI:J:48698
Mamm Genome 9(7):503-5
MGI:J:48698
Mamm Genome 9(7):503-5
1997
Brain dopamine receptor plasticity: testing a diathesis-stress hypothesis in an animal model.
Cabib S , et al.
Cabib S , et al.
PubMed:9266612
MGI:J:68169
Psychopharmacology (Berl) 132(2):153-60
MGI:J:68169
Psychopharmacology (Berl) 132(2):153-60
1997
Quantitative trait loci affecting methamphetamine responses in BXD recombinant inbred mouse strains.
Grisel JE , et al.
Grisel JE , et al.
PubMed:8987796
MGI:J:37546
J Neurosci 17(2):745-54
MGI:J:37546
J Neurosci 17(2):745-54
1997
Identification of a sex-specific quantitative trait locus mediating nonopioid stress-induced analgesia in female mice.
Mogil JS , et al.
Mogil JS , et al.
PubMed:9315917
MGI:J:43467
J Neurosci 17(20):7995-8002
MGI:J:43467
J Neurosci 17(20):7995-8002
1996
Quantitative trait loci contributing to phencyclidine-induced and amphetamine-induced locomotor behavior in inbred mice.
Alexander RC , et al.
Alexander RC , et al.
PubMed:8914121
MGI:J:36714
Neuropsychopharmacology 15(5):484-90
MGI:J:36714
Neuropsychopharmacology 15(5):484-90
1996
Nitrous oxide antinociception in BXD recombinant inbred mouse strains and identification of quantitative trait loci.
Quock RM , et al.
Quock RM , et al.
PubMed:8828582
MGI:J:34065
Brain Res 725(1):23-9
MGI:J:34065
Brain Res 725(1):23-9
1995
Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/6 and DBA/2 strains.
Belknap JK , et al.
Belknap JK , et al.
PubMed:7643715
MGI:J:28263
Life Sci 57(10):PL117-24
MGI:J:28263
Life Sci 57(10):PL117-24
1995
Localization of genes influencing ethanol-induced conditioned place preference and locomotor activity in BXD recombinant inbred mice.
Cunningham CL , et al.
Cunningham CL , et al.
PubMed:7480533
MGI:J:28135
Psychopharmacology (Berl) 120(1):28-41
MGI:J:28135
Psychopharmacology (Berl) 120(1):28-41
1995
Quantitative trait loci (QTL) for circadian rhythms of locomotor activity in mice.
Hofstetter JR , et al.
Hofstetter JR , et al.
PubMed:8540893
MGI:J:29803
Behav Genet 25(6):545-56
MGI:J:29803
Behav Genet 25(6):545-56
1995
Chromosomal mapping of loci influencing sensitivity to cocaine-induced seizures in BXD recombinant inbred strains of mice.
Miner LL , et al.
Miner LL , et al.
PubMed:7724703
MGI:J:23071
Psychopharmacology (Berl) 117(1):62-6
MGI:J:23071
Psychopharmacology (Berl) 117(1):62-6
1995
Effects of acute and repeated ethanol exposures on the locomotor activity of BXD recombinant inbred mice.
Phillips TJ , et al.
Phillips TJ , et al.
PubMed:7625557
MGI:J:25695
Alcohol Clin Exp Res 19(2):269-78
MGI:J:25695
Alcohol Clin Exp Res 19(2):269-78
1995
Genetic analysis of the corticosterone response to ethanol in BXD recombinant inbred mice.
Roberts AJ , et al.
Roberts AJ , et al.
PubMed:8748968
MGI:J:31087
Behav Neurosci 109(6):1199-208
MGI:J:31087
Behav Neurosci 109(6):1199-208
1995
Alcohol acceptance, preference, and sensitivity in mice. II. Quantitative trait loci mapping analysis using BXD recombinant inbred strains.
Rodriguez LA , et al.
Rodriguez LA , et al.
PubMed:7625571
MGI:J:25698
Alcohol Clin Exp Res 19(2):367-73
MGI:J:25698
Alcohol Clin Exp Res 19(2):367-73
1995
Identification of a locus on mouse chromosome 17 associated with high-affinity choline uptake using BXD recombinant inbred mice and quantitative trait loci analysis.
Tarricone BJ , et al.
Tarricone BJ , et al.
PubMed:7665164
MGI:J:25620
Genomics 27(1):161-4
MGI:J:25620
Genomics 27(1):161-4
1994
Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.
Crabbe JC , et al.
Crabbe JC , et al.
PubMed:8169823
MGI:J:18566
J Pharmacol Exp Ther 269(1):184-92
MGI:J:18566
J Pharmacol Exp Ther 269(1):184-92
1994
Localization of genes affecting alcohol drinking in mice.
Phillips TJ , et al.
Phillips TJ , et al.
PubMed:7978106
MGI:J:20482
Alcohol Clin Exp Res 18(4):931-41
MGI:J:20482
Alcohol Clin Exp Res 18(4):931-41
1993
Quantitative trait loci (QTL) applications to substances of abuse: physical dependence studies with nitrous oxide and ethanol in BXD mice.
Belknap JK , et al.
Belknap JK , et al.
PubMed:8512534
MGI:J:11831
Behav Genet 23(2):213-22
MGI:J:11831
Behav Genet 23(2):213-22
1993
Behavior genetic analyses of drug withdrawal.
Crabbe JC , et al.
Crabbe JC , et al.
PubMed:7748342
MGI:J:109922
Alcohol Alcohol Suppl 2:477-82
MGI:J:109922
Alcohol Alcohol Suppl 2:477-82
1992
Single-locus control of saccharin intake in BXD/Ty recombinant inbred (RI) mice: some methodological implications for RI strain analysis.
Belknap JK , et al.
Belknap JK , et al.
PubMed:1590732
MGI:J:1952
Behav Genet 22(1):81-100
MGI:J:1952
Behav Genet 22(1):81-100
1992
Quantitative trait loci associated with brain weight in the BXD/Ty recombinant inbred mouse strains.
Belknap JK , et al.
Belknap JK , et al.
PubMed:1393606
MGI:J:2827
Brain Res Bull 29(3-4):337-44
MGI:J:2827
Brain Res Bull 29(3-4):337-44
1991
Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology.
Gora-Maslak G , et al.
Gora-Maslak G , et al.
PubMed:1780413
MGI:J:39738
Psychopharmacology (Berl) 104(4):413-24
MGI:J:39738
Psychopharmacology (Berl) 104(4):413-24
1991
Use of recombinant inbred strains to detect quantitative trait loci associated with behavior.
Plomin R , et al.
Plomin R , et al.
PubMed:2049054
MGI:J:11248
Behav Genet 21(2):99-116
MGI:J:11248
Behav Genet 21(2):99-116
1984
Genetic control of thymus size in inbred mice.
Peleg L , et al.
Peleg L , et al.
PubMed:6715864
MGI:J:7417
J Hered 75(2):126-30
MGI:J:7417
J Hered 75(2):126-30
When using the BXD27/TyJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #000041 in your Materials and Methods section.
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Appearance
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BrownDetails
chocolate brownRelated Genotype: a/a Tyrp1b/Tyrp1b Myo5a+/Myo5a+
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The Jackson Laboratory ensures the genetic quality and genotyping of JAX® Mice strains before making them available to researchers. However, phenotypes may vary due to environmental conditions and may not be fully characterized. Phenotype descriptions are based on published data, and JAX does not guarantee phenotype or breeding performance.
To ensure JAX® Mice meet your research needs, we recommend:
- Genotyping mutant mice upon arrival.
- Performing pilot experiments on a small number of mice.
- Ordering more than one breeding pair to establish your colony and avoid delays.