If you need help with your order, contact Customer Support
For in-depth product & services help, ask our Technical Information Scientists
BXD2/TyJ
- Overview
- How it's Made
- How it's Used
- Husbandry
- Legal
- Related Strains
- Print
BXD2/TyJ
What Does This Nomenclature Mean?
Strain #:000075
RRID:IMSR_JAX:000075
The BXD set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes. The BXD2/TyJ strain develops spontaneous arthritis in 50% of females by 8 months of age and 90% of males greater than 12 months of age. Adult mice exhibit glomerulonephritis, proteinuria (by 6 months), splenomegaly, and autoantibody production. The BXD strains are derived from the C57BL/6J (Stock No. 000664) and DBA/2J (Stock No. 000671) progenitor strains.
View Pricing
Live Mouse
Frozen Mouse Embryo#000075
View as Pricelist
N/A
Male
Female
$3,532.00
Available
Live mice available in varying quantities. Contact Customer Service for specifics.Please contact Technical Support 
for more information.
for more information.Order Now
Details
Inventory fluctuates based on current demand. If a strain is not immediately available, an estimated lead time will be provided in 2-3 business days.
General considerations:
General considerations:
- Mice are typically delivered at 4-8 weeks of age
- Age requests are not guaranteed.
- If cohorts of mice are needed at a specific age range for experiments, inquire with Customer Service for feasibility.
How it's Made
Strain Highlights
Recombinant Inbred (RI)
Originating Article When using the BXD2/TyJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #000075 in your Materials and Methods section.
When using the BXD2/TyJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #000075 in your Materials and Methods section.Detailed Description
The BXD RI strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. The BXD set of RI strains also is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density.
The strain distribution pattern (SDP) for the BXD RI strains is available through the Mouse Genome Informatics Contributed Data Sets and Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network .
The BXD2/TyJ strain develops spontaneous arthritis in 50% of females by 8 months of age and 90% of males greater than 12 months of age. The progressive, age-related arthritis includes extensive synovial hyperplasia and marginal invasion of the metatarsophalangeal, forelimb and hindlimb joints. Adult mice exhibit glomerulonephritis, proteinuria (by 6 months), splenomegaly, and autoantibody production. (Mountz JD, et al., 2005)
Of note, the majority of pups develop hydrocephalus by 5 weeks of age. In addition some older mice develop hydrocephalus as old as 7 months of age.
Development
The BXD set of RI strains was developed in the laboratory of Benjamin Taylor and was transferred to The Jackson Laboratory from Dr. Taylor's research colony upon his retirement. Of 42 BXD RI strains originally derived from the C57BL/6J (Stock No. 000664) and DBA/2J (Stock No. 000671), a number have become extinct over the years. The other BXD RI strains now being distributed are listed under "Related Recombinant Inbred Strains."
Genetics
Genetic Background
---
---
Generation
Generation Definitions >
F48p+F17
(Last Updated: March 17th 2025)
Generation Definitions >
F48p+F17
(Last Updated: March 17th 2025)
How it's Used
JAX Physiological Data
References
Selected References
Additional References
2021
A platform for experimental precision medicine: The extended BXD mouse family.
Ashbrook DG , et al.
Ashbrook DG , et al.
PubMed:33472028
MGI:J:314802
Cell Syst 12(3):235-247.e9
MGI:J:314802
Cell Syst 12(3):235-247.e9
2005
Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of mice.
Mountz JD , et al.
Mountz JD , et al.
PubMed:15683449
MGI:J:96064
Scand J Immunol 61(2):128-38
MGI:J:96064
Scand J Immunol 61(2):128-38
2000
Quantitative trait loci affecting ethanol sensitivity in BXD recombinant inbred mice.
Browman KE , et al.
Browman KE , et al.
PubMed:10656187
MGI:J:66463
Alcohol Clin Exp Res 24(1):17-23
MGI:J:66463
Alcohol Clin Exp Res 24(1):17-23
1998
Provisional mapping of quantitative trait loci for chronic ethanol withdrawal severity in BXD recombinant inbred mice.
Crabbe JC , et al.
Crabbe JC , et al.
PubMed:9655868
MGI:J:49185
J Pharmacol Exp Ther 286(1):263-71
MGI:J:49185
J Pharmacol Exp Ther 286(1):263-71
1995
Alcohol acceptance, preference, and sensitivity in mice. II. Quantitative trait loci mapping analysis using BXD recombinant inbred strains.
Rodriguez LA , et al.
Rodriguez LA , et al.
PubMed:7625571
MGI:J:25698
Alcohol Clin Exp Res 19(2):367-73
MGI:J:25698
Alcohol Clin Exp Res 19(2):367-73
1994
Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.
Crabbe JC , et al.
Crabbe JC , et al.
PubMed:8169823
MGI:J:18566
J Pharmacol Exp Ther 269(1):184-92
MGI:J:18566
J Pharmacol Exp Ther 269(1):184-92
When using the BXD2/TyJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #000075 in your Materials and Methods section.
Legal
Terms of Use
View General Terms and Conditions
Licensing Information
Phone: 207-288-6470
Email: TechTran@jax.org
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory's Genotyping Promise
The Jackson Laboratory ensures the genetic quality and genotyping of JAX® Mice strains before making them available to researchers. However, phenotypes may vary due to environmental conditions and may not be fully characterized. Phenotype descriptions are based on published data, and JAX does not guarantee phenotype or breeding performance.
To ensure JAX® Mice meet your research needs, we recommend:
- Genotyping mutant mice upon arrival.
- Performing pilot experiments on a small number of mice.
- Ordering more than one breeding pair to establish your colony and avoid delays.