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BXA4/PgnJ
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BXA4/PgnJ
What Does This Nomenclature Mean?
Strain #:001694
RRID:IMSR_JAX:001694
The AXB and BXA set of RI strains are useful in the genetic analysis of complex diseases. The individual strains within the RI set also differ in their susceptibility to infectious diseases and in their responses to alcohol, stress, and endotoxin. AXB and BXA strains are derived from the C57BL/6J (Stock No. 000664) and A/J (Stock No. 000646) progenitor strains.
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How it's Made
Strain Highlights
Recombinant Inbred (RI)
Originating Article When using the BXA4/PgnJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #001694 in your Materials and Methods section.
When using the BXA4/PgnJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #001694 in your Materials and Methods section.Detailed Description
The AXB and BXA set of RI strains are useful in the genetic analysis of several complex diseases including cardiovascular disease, diabetes, cancer, cleft palate, and hydrocephalus. The individual strains within the RI set also differ in their susceptibility to infectious diseases and in their responses to alcohol, stress, and endotoxin.
The strain distribution pattern (SDP) for the BXA RI strains is available through the Mouse Genome Informatics Contributed Data Sets and Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network .
Development
The AXB and BXA recombinant inbred (RI) set of strains were originally generated and maintained at the University of California, San Diego, and have been imported into The Jackson Laboratory. There were originally 51 AXB and BXA strains derived from the C57BL/6J (Stock No. 000664) and A/J (Stock No. 000646) progenitor strains. Many of the original strains are either extinct or were discarded due to genetic contamination. Please refer to Sampson et al., 1998 for more information.
Genetics
Genetic Background
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Generation
Generation Definitions >
F51
(Last Updated: March 11th 1994)
Generation Definitions >
F51
(Last Updated: March 11th 1994)
Allele Symbol Nrg3ska 
Allele Name
scaramanga
Gene Symbol
Nrg3
Allele Type
Spontaneous
Gene Name
neuregulin 3
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How it's Used
JAX Physiological Data
References
Additional References
Allele References
2013
Genetic linkages for thyroxine released in response to thyrotropin stimulation in three sets of recombinant inbred mice provide evidence for shared and novel genes controlling thyroid function.
Hamidi S , et al.
Hamidi S , et al.
PubMed:22988948
MGI:J:204730
Thyroid 23(3):360-70
MGI:J:204730
Thyroid 23(3):360-70
2011
Distinct genetic signatures for variability in total and free serum thyroxine levels in four sets of recombinant inbred mice.
McLachlan SM , et al.
McLachlan SM , et al.
PubMed:21209025
MGI:J:173883
Endocrinology 152(3):1172-9
MGI:J:173883
Endocrinology 152(3):1172-9
2007
Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in recombinant inbred mice.
Llamas B , et al.
Llamas B , et al.
PubMed:17566079
MGI:J:127219
Physiol Genomics 31(2):176-82
MGI:J:127219
Physiol Genomics 31(2):176-82
2006
Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice.
Martin MV , et al.
Martin MV , et al.
PubMed:17081266
MGI:J:117408
Genes Brain Behav 5(8):614-23
MGI:J:117408
Genes Brain Behav 5(8):614-23
1998
Genetic analysis of behavioral, neuroendocrine, and biochemical parameters in inbred rodents: initial studies in Lewis and Fischer 344 rats and in A/J and C57BL/6J mice.
Brodkin ES , et al.
Brodkin ES , et al.
PubMed:9733917
MGI:J:50636
Brain Res 805(1-2):55-68
MGI:J:50636
Brain Res 805(1-2):55-68
1998
Alcohol preference in AXB/BXA recombinant inbred mice: gender differences and gender-specific quantitative trait loci.
Gill K , et al.
Gill K , et al.
PubMed:9880655
MGI:J:52467
Mamm Genome 9(12):929-35
MGI:J:52467
Mamm Genome 9(12):929-35
1998
An edited linkage map for the AXB and BXA recombinant inbred mouse strains.
Sampson SB , et al.
Sampson SB , et al.
PubMed:9716653
MGI:J:45463
Mamm Genome 9(9):688-94
MGI:J:45463
Mamm Genome 9(9):688-94
1993
Strain distribution pattern in AXB and BXA recombinant inbred strains for loci on murine chromosomes 10, 13, 17, and 18.
Mu JL , et al.
Mu JL , et al.
PubMed:8094988
MGI:J:4133
Mamm Genome 4(3):148-52
MGI:J:4133
Mamm Genome 4(3):148-52
1992
The AXB and BXA set of recombinant inbred mouse strains.
Marshall JD , et al.
Marshall JD , et al.
PubMed:1477475
MGI:J:3516
Mamm Genome 3(12):669-80
MGI:J:3516
Mamm Genome 3(12):669-80
When using the BXA4/PgnJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #001694 in your Materials and Methods section.
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G200 (Maximum)Appearance
Coat Color
AlbinoDetails
albinoRelated Genotype: a/a Tyrp1b/Tyrp1b Tyrc/Tyrc
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The Jackson Laboratory's Genotyping Promise
The Jackson Laboratory ensures the genetic quality and genotyping of JAX® Mice strains before making them available to researchers. However, phenotypes may vary due to environmental conditions and may not be fully characterized. Phenotype descriptions are based on published data, and JAX does not guarantee phenotype or breeding performance.
To ensure JAX® Mice meet your research needs, we recommend:
- Genotyping mutant mice upon arrival.
- Performing pilot experiments on a small number of mice.
- Ordering more than one breeding pair to establish your colony and avoid delays.