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Cryo RecoveryCryo-Recovered Mouse
#001681
Inbred
1 pair minimum
Mice Available In 12 Weeks.Contact Customer Service for more information.
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WHAT TO EXPECT
  • A confirmation will be sent after order placement.
  • Typically, eight or more animals are produced.
  • The total number, sex and genotypes will be provided to you prior to scheduling shipment.
  • Additional breeding may be required to produce the genotype(s) of interest
  • If we fail to produce the animals of the correct genotype, you will not be charged, unless this is designated as "fee for service" project
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How it's Made

Strain Highlights
Strain Type
Recombinant Inbred (RI)
Originating Article
Originating Article
Info When using the AXB10/PgnJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #001681 in your Materials and Methods section.
Detailed Description
The AXB and BXA set of RI strains are useful in the genetic analysis of several complex diseases including cardiovascular disease, diabetes, cancer, cleft palate, and hydrocephalus. The individual strains within the RI set also differ in their susceptibility to infectious diseases and in their responses to alcohol, stress, and endotoxin.

The strain distribution pattern (SDP) for the AXB RI strains is available through the Mouse Genome Informatics Contributed Data Sets and Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network .

Development
The AXB and BXA recombinant inbred (RI) set of strains were originally generated and maintained at the University of California, San Diego, and have been imported into The Jackson Laboratory. There were originally 51 AXB and BXA strains derived from the C57BL/6J (Stock No. 000664) and A/J (Stock No. 000646) progenitor strains. Many of the original strains are either extinct or were discarded due to genetic contamination. Please refer to Sampson et al., 1998 for more information.
Genetics
Genetic Background
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Generation
Generation Definitions >
F49
(Last Updated: October 14th 1992)
Allele Symbol Nrg3ska ExternalLink
Allele Name
scaramanga
Gene Symbol
Nrg3
Allele Type
Spontaneous
Gene Name
neuregulin 3
Gene Synonym(s)
HRG3,pro-NRG3,ska,
Site of Expression
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Expressed Gene(s)
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Strain of Origin
A/J
Chromosome
14
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How it's Used

References
2013
Genetic linkages for thyroxine released in response to thyrotropin stimulation in three sets of recombinant inbred mice provide evidence for shared and novel genes controlling thyroid function.
Hamidi S , et al.
PubMed:22988948
MGI:J:204730
Thyroid 23(3):360-70
2011
Distinct genetic signatures for variability in total and free serum thyroxine levels in four sets of recombinant inbred mice.
McLachlan SM , et al.
PubMed:21209025
MGI:J:173883
Endocrinology 152(3):1172-9
2007
Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in recombinant inbred mice.
Llamas B , et al.
PubMed:17566079
MGI:J:127219
Physiol Genomics 31(2):176-82
2006
Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice.
Martin MV , et al.
PubMed:17081266
MGI:J:117408
Genes Brain Behav 5(8):614-23
1998
Genetic analysis of behavioral, neuroendocrine, and biochemical parameters in inbred rodents: initial studies in Lewis and Fischer 344 rats and in A/J and C57BL/6J mice.
Brodkin ES , et al.
PubMed:9733917
MGI:J:50636
Brain Res 805(1-2):55-68
1998
Alcohol preference in AXB/BXA recombinant inbred mice: gender differences and gender-specific quantitative trait loci.
Gill K , et al.
PubMed:9880655
MGI:J:52467
Mamm Genome 9(12):929-35
1998
An edited linkage map for the AXB and BXA recombinant inbred mouse strains.
Sampson SB , et al.
PubMed:9716653
MGI:J:45463
Mamm Genome 9(9):688-94
1993
Strain distribution pattern in AXB and BXA recombinant inbred strains for loci on murine chromosomes 10, 13, 17, and 18.
Mu JL , et al.
PubMed:8094988
MGI:J:4133
Mamm Genome 4(3):148-52
1992
The AXB and BXA set of recombinant inbred mouse strains.
Marshall JD , et al.
PubMed:1477475
MGI:J:3516
Mamm Genome 3(12):669-80
When using the AXB10/PgnJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #001681 in your Materials and Methods section.
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