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C3.SW-H2b/SnJ

What Does This Nomenclature Mean?
Strain #:000438
RRID:IMSR_JAX:000438Info
 | Also Known As: C3H.H2b
Male mice from the C3.SW-H2b/SnJ congenic strain are predisposed to maturity-onset impairment of glucose tolerance and hyperinsulinemia with some mice exhibiting hyperglycemia, and they are susceptible to the diabetogenic effects of multiple low doses of streptozotocin. In addition these mice have been used in many different immunological studies.
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Live MouseLive Mouse
#000438
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Homozygous for H2<b>
Male
Female
$226.00
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  • Mice are typically delivered at 4-8 weeks of age
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How it's Made

Strain Highlights
Strain Type
Congenic
Strain Type
Major Histocompatibility Congenic
Originating Article
Originating Article
Info When using the C3.SW-H2b/SnJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #000438 in your Materials and Methods section.
Detailed Description
Male mice from the C3.SW-H2b/SnJ congenic strain are predisposed to maturity-onset impairment of glucose tolerance and hyperinsulinemia with some mice exhibiting hyperglycemia. Symptoms occur much later, between 5 and 8 months of age, than most of the single gene obese and diabetic strains. In addition, male mice are susceptible to the diabetogenic effects of multiple low doses of streptozotocin (40 mg/kg BW.day X 5).
Development
This strain was created, beginning in 1948, by George Snell by transferring the H2b haplotype from a mouse of an outbred Swiss stock onto the C3H/HeDiSn inbred strain by 11 rounds of backcross-intercross breeding (Snell 1958).
Genetics
Genetic Background
000661 C3H/HeSnJ
Generation
Generation Definitions >
F143pF14
(Last Updated: March 18th 2025)
Allele Symbol H2b ExternalLink
Allele Name
b variant
Gene Symbol
H2
Allele Type
Not Applicable
Gene Name
histocompatibility-2, MHC
Gene Synonym(s)
H-2,MHC-II,
Site of Expression
---
Expressed Gene(s)
---
Strain of Origin
Not Applicable
Chromosome
17
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Allele Symbol B2ma ExternalLink
Allele Name
a variant
Gene Symbol
B2m
Allele Type
Spontaneous
Gene Name
beta-2 microglobulin
Gene Synonym(s)
AMYLD6,beta 2 microglobulin,beta2-m, ... AMYLD6, beta 2 microglobulin, beta2-m, IMD43, Ly-m11, MHC1D4,
Site of Expression
---
Expressed Gene(s)
---
Strain of Origin
multiple strains
Chromosome
2
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Husbandry

Genotyping Protocols
Genotyping Resources and Troubleshooting >
Allele Symbol H2<b>
Allele Specific Protocols
Allele Symbol H2<b>-EP
Allele Specific Protocols
Animal Health Reports
Facility Barrier Level Descriptions >
imgPDF AX18 (Maximum)
Breeding Strategy
Homozygote x Homozygote
Appearance
Details

agouti
Related Genotype: A/A
Dietary Information
New Diet as of March 2015: Lab Diet® 5K0Q (6% fat)