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SF/CamEiJ

What Does This Nomenclature Mean?
Strain #:000280
RRID:IMSR_JAX:000280Info
SF/Cam was derived from wild mice caught in an area outside San Francisco, CA and sibling mated with selection for late sexual maturity in males. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research. This strain will be removed from the shelf on April 30, 2025. If you want any mice from this strain please place your order now.
Important Note: This strain will be removed from the shelf on April 30, 2025. If you want any mice from this strain please place your order now.
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How it's Made

Strain Highlights
Strain Type
Inbred Strain
Strain Type
Wild-Derived
Originating Article
Originating Article
Info When using the SF/CamEiJ mouse strain in a publication, please include JAX stock #000280 in your Materials and Methods section.

Detailed Description
SF/Cam was derived from wild mice caught in an area outside San Francisco, CA and sibling mated with selection for late sexual maturity in males. Female mice exhibit a large adrenal X zone (a transient area formed by basophilic cells surrounding the adrenal medulla) and a poorly developed adrenal zona glomerulosa. Males exhibit high serum complement activity. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.

In 2019-2020, researchers at The Jackson Laboratory discovered this inbred strain contains the Trem2S148E allele - a naturally occurring variant at position 48351151-48351152 on Chr 17 (rs108080490 and rs107649577; Ensembl GRCm38.p6). This TC to GA transition results in a serine to glutamic acid substitution at amino acid 148 (S148E).

Development
In 1951, wild mice were trapped by RL Rudd, University of California at Davis, in a salt marsh approximately 2 miles east of Corte Madera, Marin County, California. Mice were sibling mated until F10 by M Barnawell, University of Nebraska, Lincoln, then at the University of California at Berkeley. Barnawell transferred mice to ME Wallace, University of Cambridge in 1959. Wallace transferred mice to EM Eicher and TH Roderick at The Jackson Laboratory in 1971. This strain reached F98 at The Jackson Laboratory in 2003.

Genetics
Genetic Background
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Generation
Generation Definitions >

(Last Updated: July 4th 2018)
Allele Symbol Ahrb-2 ExternalLink
Allele Name
b-2 variant
Gene Symbol
Ahr
Allele Type
Not Applicable
Gene Name
aryl-hydrocarbon receptor
Gene Synonym(s)
Ah,Ahh,Ahre, ... Ah, Ahh, Ahre, bHLHe76, dioxin receptor, FVH3, In, RP85,
Site of Expression
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Expressed Gene(s)
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Strain of Origin
BALB/cBy
Chromosome
12
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Allele Symbol Mx1s1 ExternalLink
Allele Name
myxovirus susceptibility 1
Gene Symbol
Mx1
Allele Type
Spontaneous
Gene Name
MX dynamin-like GTPase 1
Gene Synonym(s)
IFI78,IFI-78K,lncMX1-215, ... IFI78, IFI-78K, lncMX1-215, MX, Mx-1, MxA, MXB, myxovirus (influenza) resistance 1 polypeptide,
Site of Expression
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Expressed Gene(s)
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Strain of Origin
multiple strains
Chromosome
16
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Allele Symbol B2ma ExternalLink
Allele Name
a variant
Gene Symbol
B2m
Allele Type
Spontaneous
Gene Name
beta-2 microglobulin
Gene Synonym(s)
AMYLD6,beta 2 microglobulin,beta2-m, ... AMYLD6, beta 2 microglobulin, beta2-m, IMD43, Ly-m11, MHC1D4,
Site of Expression
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Expressed Gene(s)
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Strain of Origin
multiple strains
Chromosome
2
More
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